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Not to be confused with NP0 (ending is zero).

NPO may refer to:

  • Nil per os, Latin for "nothing by mouth", a medical instruction to withhold oral intake of food and fluids
  • Nonprofit organization
  • National Ports Organisation, a British governmental organisation set up by Barbara Castle MP
  • National Preservation Office, part of the British Library
  • Nauchno-Proizvodstvennoye Obyedineniye (Научно-производственное объединение, Russian for "Scientific and Production Establishment"), title often found in the names of successors to the Experimental Design Bureaux (OKB) of Communist times
  • Nederlandse Publieke Omroep (organization) (in English: "Netherlands Public Broadcasting"), abbreviated as NPO, the Dutch public broadcasting organization that administers the public broadcasting service in the Netherlands
  • Netherlands Pathfinder Organisation (Nederlandse Padvinders Organisatie), one of the organisations that evolved into Scouting Nederland, the national Scouting organisation
  • North Pacific Oscillation, an atmospheric teleconnection pattern
  • NP optimization problem, optimization problems that are NP-hard
  • NPO UK Ltd., a company which had stationery and book shops around Northern Ireland, bought by and rebranded Eason & Son