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NPSL may refer to:
- National Premier Soccer League, an American soccer league established in 2003, considered to be at the fourth level of the American soccer pyramid
- National Professional Soccer League (1967), an American outdoor soccer league active in 1967
- National Professional Soccer League (1984–2001), an American indoor soccer league active from 1984–2001
- National Professional Soccer League (South Africa), a South African soccer league active from 1971–1995
| disambiguation page lists articles associated with the title NPSL.
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