NRCAM

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NRCAM
Protein NRCAM PDB 1uen.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNRCAM, neuronal cell adhesion molecule
External IDsOMIM: 601581 MGI: 104750 HomoloGene: 21041 GeneCards: NRCAM
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for NRCAM
Genomic location for NRCAM
Band7q31.1Start108,147,623 bp[1]
End108,456,717 bp[1]
RNA expression pattern
PBB GE NRCAM 204105 s at fs.png

PBB GE NRCAM 216959 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001146031
NM_176930

RefSeq (protein)

NP_001032209
NP_001180511
NP_001180512
NP_001180513
NP_005001

NP_001139503
NP_795904

Location (UCSC)Chr 7: 108.15 – 108.46 MbChr 12: 44.33 – 44.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.[5][6]

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism[7] and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000091129 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020598 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Lane RP, Chen XN, Yamakawa K, Vielmetter J, Korenberg JR, Dreyer WJ (Dec 1996). "Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31". Genomics. 35 (3): 456–65. doi:10.1006/geno.1996.0385. PMID 8812479.
  6. ^ a b "Entrez Gene: NRCAM neuronal cell adhesion molecule".
  7. ^ Marui T, Funatogawa I, Koishi S, et al. (2008). "Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism". Int J Neuropsychopharmacol. 12 (1): 1–10. doi:10.1017/S1461145708009127. PMID 18664314.

Further reading[edit]