NRF1

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NRF1
Identifiers
Aliases NRF1, ALPHA-PAL, nuclear respiratory factor 1
External IDs MGI: 1332235 HomoloGene: 3674 GeneCards: NRF1
RNA expression pattern
PBB GE NRF1 204652 s at fs.png

PBB GE NRF1 204651 at fs.png

PBB GE NRF1 211279 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005011
NM_001040110
NM_001293163
NM_001293164

RefSeq (protein)

NP_001035199
NP_001280092
NP_001280093
NP_005002

Location (UCSC) Chr 7: 129.61 – 129.76 Mb Chr 6: 30.05 – 30.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1.[citation needed]

Function[edit]

Nrf1 functions as a transcription factor that activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for mitochondrial respiration, and mitochondrial DNA transcription and replication. Nrf1, together with Nrf2, mediates the biogenomic coordination between nuclear and mitochondrial genomes by directly regulating the expression of several nuclear-encoded ETC proteins, and indirectly regulating the three mitochondrial-encoded COX subunit genes by activating mtTFA, mtTFB1, and mtTFB2.

Nrf1 is associated with the regulation of neurite outgrowth.[3]

Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized.[4]

Cyclin D1-dependent kinase, through phosphorylating NRF-1 at S47, coordinates nuclear DNA synthesis and mitochondrial function.[5]

Interactions[edit]

NRF1 has been shown to interact with DYNLL1[6] and PPARGC1A.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Chang WT, Chen HI, Chiou RJ, Chen CY, Huang AM (August 2005). "A novel function of transcription factor alpha-Pal/NRF-1: increasing neurite outgrowth". Biochem. Biophys. Res. Commun. 334 (1): 199–206. doi:10.1016/j.bbrc.2005.06.079. PMID 15992771. 
  4. ^ "Entrez Gene: NRF1 nuclear respiratory factor 1". 
  5. ^ Wang C, Li Z, Lu Y, Du R, Katiyar S, Yang J, Fu M, Leader JE, Quong A, Novikoff PM, Pestell RG (2006). "Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function". Proceedings of the National Academy of Sciences. 103 (31): 11567–72. Bibcode:2006PNAS..10311567W. doi:10.1073/pnas.0603363103. JSTOR 30051572. PMC 1518800Freely accessible. PMID 16864783. 
  6. ^ Herzig RP, Andersson U, Scarpulla RC (December 2000). "Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila". J. Cell. Sci. 113 (23): 4263–73. PMID 11069771. 
  7. ^ Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM (July 1999). "Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1". Cell. 98 (1): 115–24. doi:10.1016/S0092-8674(00)80611-X. PMID 10412986. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.