Neuregulin 3

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For the stimulant, see NRG-3.
NRG3
Identifiers
Aliases NRG3, HRG3, pro-neuregulin 3
External IDs MGI: 1097165 HomoloGene: 32051 GeneCards: NRG3
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001010848
NM_001165972
NM_001165973

NM_001190187
NM_001190188
NM_008734

RefSeq (protein)

NP_001010848.2
NP_001159445.1

NP_032760.1

Location (UCSC) Chr 10: 81.88 – 82.99 Mb Chr 14: 38.37 – 39.47 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Neuregulin 3 also known as NRG3 is a member of the neuregulin protein family which in humans is encoded by the NRG3 gene.[3][4]

Function[edit]

NRG3 can bind to the extracellular domain of the ERBB4 receptor tyrosine kinase but not to the related family members ERBB2 or ERBB3. NRG3 binding stimulates tyrosine phosphorylation of ERBB4.[4]

Clinical significance[edit]

Variants of the NRG3 gene have been linked to a susceptibility to schizophrenia.[5]

It has also been linked to Hirschsprung's disease.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: NRG3 neuregulin 3". 
  4. ^ a b Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ (September 1997). "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9562–7. doi:10.1073/pnas.94.18.9562. PMC 23218Freely accessible. PMID 9275162. 
  5. ^ Chen PL, Avramopoulos D, Lasseter VK, McGrath JA, Fallin MD, Liang KY, Nestadt G, Feng N, Steel G, Cutting AS, Wolyniec P, Pulver AE, Valle D (January 2009). "Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia". Am. J. Hum. Genet. 84 (1): 21–34. doi:10.1016/j.ajhg.2008.12.005. PMC 2668048Freely accessible. PMID 19118813. Lay summaryThe Johns Hopkins News-Letter. 
  6. ^ Yang J, Duan S, Zhong R, Yin J, Pu J, Ke J, Lu X, Zou L, Zhang H, Zhu Z, Wang D, Xiao H, Guo A, Xia J, Miao X, Tang S, Wang G (January 2013). "Exome Sequencing Identified NRG3 as a Novel Susceptible Gene of Hirschsprung's Disease in a Chinese Population". Mol. Neurobiol. 47: 957–966. doi:10.1007/s12035-012-8392-4. PMID 23315268. 

Further reading[edit]