Neuregulin 4

From Wikipedia, the free encyclopedia
  (Redirected from NRG4)
Jump to: navigation, search
NRG4
Identifiers
Aliases NRG4, HRG4, neuregulin 4
External IDs MGI: 1933833 HomoloGene: 12921 GeneCards: NRG4
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_138573

NM_032002

RefSeq (protein)

NP_612640

NP_114391

Location (UCSC) Chr 15: 75.94 – 76.06 Mb Chr 9: 55.22 – 55.33 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.[3][4][5]

Function[edit]

The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation.[5]

Clinical significance[edit]

Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: NRG4 neuregulin 4". 
  4. ^ Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241Freely accessible. PMID 12477932. doi:10.1073/pnas.242603899. 
  5. ^ a b Harari D, Tzahar E, Romano J, Shelly M, Pierce JH, Andrews GC, Yarden Y (April 1999). "Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase". Oncogene. 18 (17): 2681–9. PMID 10348342. doi:10.1038/sj.onc.1202631. 
  6. ^ Memon AA, Sorensen BS, Melgard P, Fokdal L, Thykjaer T, Nexo E (December 2004). "Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients". Br. J. Cancer. 91 (12): 2034–41. PMC 2409781Freely accessible. PMID 15583696. doi:10.1038/sj.bjc.6602251. 

Further reading[edit]