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Neuregulin 4
Symbols NRG4 ; HRG4
External IDs OMIM610894 MGI1933833 HomoloGene12921 GeneCards: NRG4 Gene
Species Human Mouse
Entrez 145957 83961
Ensembl ENSG00000169752 ENSMUSG00000032311
UniProt Q8WWG1 Q9WTX4
RefSeq (mRNA) NM_138573 NM_032002
RefSeq (protein) NP_612640 NP_114391
Location (UCSC) Chr 15:
75.94 – 76.06 Mb
Chr 9:
55.22 – 55.33 Mb
PubMed search [1] [2]

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.[1][2][3]


The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation.[3]

Clinical significance[edit]

Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.[4]


  1. ^ "Entrez Gene: NRG4 neuregulin 4". 
  2. ^ Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  3. ^ a b Harari D, Tzahar E, Romano J, Shelly M, Pierce JH, Andrews GC, Yarden Y (April 1999). "Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase". Oncogene 18 (17): 2681–9. doi:10.1038/sj.onc.1202631. PMID 10348342. 
  4. ^ Memon AA, Sorensen BS, Melgard P, Fokdal L, Thykjaer T, Nexo E (December 2004). "Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients". Br. J. Cancer 91 (12): 2034–41. doi:10.1038/sj.bjc.6602251. PMC 2409781. PMID 15583696. 

Further reading[edit]