NRXN2

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
NRXN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNRXN2, neurexin 2
External IDsOMIM: 600566 MGI: 1096362 HomoloGene: 86984 GeneCards: NRXN2
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for NRXN2
Genomic location for NRXN2
Band11q13.1Start64,606,174 bp[1]
End64,723,188 bp[1]
RNA expression pattern
PBB GE NRXN2 209983 s at fs.png

PBB GE NRXN2 209982 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015080
NM_138732
NM_138734

NM_001205234
NM_001205235
NM_020253

RefSeq (protein)

NP_055895
NP_620060
NP_620063
NP_055895.1
NP_620060.1

NP_001192163
NP_001192164
NP_064649
NP_001356292

Location (UCSC)Chr 11: 64.61 – 64.72 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Neurexin-2-alpha is a protein that in humans is encoded by the NRXN2 gene.[4][5]

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110076 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Ushkaryov YA, Petrenko AG, Geppert M, Sudhof TC (Aug 1992). "Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin". Science. 257 (5066): 50–56. doi:10.1126/science.1621094. PMID 1621094.
  5. ^ a b "Entrez Gene: NRXN2 neurexin 2".

Further reading[edit]