NRXN2

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NRXN2
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases NRXN2
External IDs MGI: 1096362 HomoloGene: 86984 GeneCards: NRXN2
RNA expression pattern
PBB GE NRXN2 209983 s at fs.png

PBB GE NRXN2 209982 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015080
NM_138732
NM_138734

NM_001205234
NM_001205235
NM_020253

RefSeq (protein)

NP_620063.1
NP_055895.1
NP_620060.1

n/a

Location (UCSC) Chr 11: 64.61 – 64.72 Mb Chr 19: 6.42 – 6.54 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Neurexin-2-alpha is a protein that in humans is encoded by the NRXN2 gene.[3][4]

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ushkaryov YA, Petrenko AG, Geppert M, Sudhof TC (Aug 1992). "Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin". Science. 257 (5066): 50–56. doi:10.1126/science.1621094. PMID 1621094. 
  4. ^ a b "Entrez Gene: NRXN2 neurexin 2". 

Further reading[edit]