NSFL1C

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NSFL1C
Protein NSFL1C PDB 1i42.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NSFL1C, P47, UBX1, UBXD10, UBXN2C, dJ776F14.1, NSFL1 cofactor
External IDs MGI: 3042273 HomoloGene: 41114 GeneCards: NSFL1C
RNA expression pattern
PBB GE NSFL1C 217830 s at fs.png

PBB GE NSFL1C 220248 x at fs.png

PBB GE NSFL1C 217831 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001206736
NM_016143
NM_018839
NM_182483

NM_001291074
NM_198326

RefSeq (protein)

NP_001193665
NP_057227
NP_061327

NP_001278003.1
NP_938085.1
NP_001278003
NP_938085

Location (UCSC) Chr 20: 1.44 – 1.47 Mb Chr 2: 151.49 – 151.51 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

NSFL1 cofactor p47 is a protein that in humans is encoded by the NSFL1C gene.[3][4]

N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Multiple transcript variants encoding several different isoforms have been found for this gene.[4]

Interactions[edit]

NSFL1C has been shown to interact with Valosin-containing protein.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934Freely accessible. PMID 11042152. 
  4. ^ a b "Entrez Gene: NSFL1C NSFL1 (p97) cofactor (p47)". 
  5. ^ Uchiyama, Keiji; Jokitalo Eija; Lindman Mervi; Jackman Mark; Kano Fumi; Murata Masayuki; Zhang Xiaodong; Kondo Hisao (Jun 2003). "The localization and phosphorylation of p47 are important for Golgi disassembly–assembly during the cell cycle". J. Cell Biol. United States. 161 (6): 1067–79. doi:10.1083/jcb.200303048. ISSN 0021-9525. PMC 2173005Freely accessible. PMID 12810701. 

Further reading[edit]