NSP4 (rotavirus)

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The rotavirus nonstructural protein NSP4 was the first viral enterotoxin discovered. It induces diarrhea and causes Ca2+-dependent transepithelial secretion.[1]


  1. ^ Dong, Y.; Zeng, CQ; Ball, JM; Estes, MK; Morris, AP (1997). "The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1,4,5-trisphosphate production". Proceedings of the National Academy of Sciences. 94 (8): 3960–5. PMC 20550Freely accessible. PMID 9108087. doi:10.1073/pnas.94.8.3960.