Netrin 1

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NTN1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NTN1, NTN1L, netrin 1
External IDs MGI: 105088 HomoloGene: 21008 GeneCards: NTN1
Genetically Related Diseases
breast cancer[1]
RNA expression pattern
PBB GE NTN1 208005 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004822

NM_008744

RefSeq (protein)

NP_004813

NP_032770.2
NP_032770

Location (UCSC) Chr 17: 9.02 – 9.24 Mb Chr 11: 68.21 – 68.4 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Netrin-1 is a protein that in humans is encoded by the NTN1 gene.[4][5]

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.[5]

Interactions[edit]

NTN1 has been shown to interact with Deleted in Colorectal Cancer.[4][6]

References[edit]

  1. ^ "Diseases that are genetically associated with NTN1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, Look AT, Fearon ER (Apr 1999). "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas". Cell Growth Differ. 10 (1): 35–42. PMID 9950216. 
  5. ^ a b "Entrez Gene: NTN1 netrin 1". 
  6. ^ Geisbrecht, Brian V; Dowd Kimberly A; Barfield Ronald W; Longo Patti A; Leahy Daniel J (Aug 2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. United States. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. ISSN 0021-9258. PMID 12810718. 

Further reading[edit]

External links[edit]