Netrin 1

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Available structures
PDBOrtholog search: PDBe RCSB
AliasesNTN1, NTN1L, netrin 1, MRMV4
External IDsOMIM: 601614 MGI: 105088 HomoloGene: 21008 GeneCards: NTN1
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for NTN1
Genomic location for NTN1
Band17p13.1Start9,021,510 bp[1]
End9,244,000 bp[1]
RNA expression pattern
PBB GE NTN1 208005 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 17: 9.02 – 9.24 MbChr 11: 68.21 – 68.4 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Netrin-1 is a protein that in humans is encoded by the NTN1 gene.[5][6]

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.[6]


NTN1 has been shown to interact with Deleted in Colorectal Cancer.[5][7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065320 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020902 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, Look AT, Fearon ER (January 1999). "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas". Cell Growth Differ. 10 (1): 35–42. PMID 9950216.
  6. ^ a b "Entrez Gene: NTN1 netrin 1".
  7. ^ Geisbrecht, Brian V; Dowd Kimberly A; Barfield Ronald W; Longo Patti A; Leahy Daniel J (Aug 2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. United States. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. ISSN 0021-9258. PMID 12810718.

Further reading[edit]

Varadarajan, Supraja G., et al. "Netrin1 produced by neural progenitors, not floor plate cells, is required for axon guidance in the spinal cord." Neuron 94.4 (2017): 790-799.

External links[edit]