Nucleobindin 1

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NUCB1
Protein NUCB1 PDB 1snl.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUCB1, CALNUC, NUC, nucleobindin 1
External IDsMGI: 97388 HomoloGene: 4507 GeneCards: NUCB1
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for NUCB1
Genomic location for NUCB1
Band19q13.33Start48,900,050 bp[1]
End48,923,372 bp[1]
RNA expression pattern
PBB GE NUCB1 200649 at fs.png

PBB GE NUCB1 200646 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006184

NM_001163662
NM_008749

RefSeq (protein)

NP_006175

NP_001157134
NP_032775

Location (UCSC)Chr 19: 48.9 – 48.92 MbChr 7: 45.49 – 45.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleobindin-1 (NUCB1), also known as calnuc, is a protein that in humans is encoded by the NUCB1 gene.[5][6]

Structure[edit]

The human calnuc protein contains 461 amino acids and has a pI of 4.9.[7]

The protein contains the following regions and domains:

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104805 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030824 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Miura K, Hirai M, Kanai Y, Kurosawa Y (Feb 1997). "Organization of the human gene for nucleobindin (NUC) and its chromosomal assignment to 19q13.2-q13.4". Genomics. 34 (2): 181–6. doi:10.1006/geno.1996.0263. PMID 8661046.
  6. ^ "Entrez Gene: NUCB1 nucleobindin 1".
  7. ^ a b Lin P, Le-Niculescu H, Hofmeister R, McCaffery JM, Jin M, Hennemann H, McQuistan T, De Vries L, Farquhar MG (June 1998). "The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein". J. Cell Biol. 141 (7): 1515–27. doi:10.1083/jcb.141.7.1515. PMC 2132997. PMID 9647645.
  8. ^ a b Miura K, Titani K, Kurosawa Y, Kanai Y (August 1992). "Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure". Biochem. Biophys. Res. Commun. 187 (1): 375–80. doi:10.1016/S0006-291X(05)81503-7. PMID 1520323.
  9. ^ Kanuru M, Raman R, Aradhyam GK (January 2013). "Serine protease activity of calnuc: regulation by Zn2+ and G proteins". J. Biol. Chem. 288 (3): 1762–73. doi:10.1074/jbc.M112.382846. PMC 3548486. PMID 23195954.

Further reading[edit]