Nucleoporin 107

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NUP107
Protein NUP107 PDB 3CQC.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NUP107, NUP84, NPHS11, nucleoporin 107kDa
External IDs MGI: 2143854 HomoloGene: 5555 GeneCards: 57122
RNA expression pattern
PBB GE NUP107 218768 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020401

NM_134010

RefSeq (protein)

NP_065134.1

NP_598771.1

Location (UCSC) Chr 12: 68.69 – 68.75 Mb Chr 10: 117.75 – 117.79 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene.[3][4][5]

Function[edit]

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[5]

Interactions[edit]

NUP107 has been shown to interact with NUP133.[6][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Boehmer T, Enninga J, Dales S, Blobel G, Zhong H (Feb 2003). "Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex". Proceedings of the National Academy of Sciences of the United States of America. 100 (3): 981–5. doi:10.1073/pnas.252749899. PMC 298712free to read. PMID 12552102. 
  4. ^ Walther TC, Alves A, Pickersgill H, Loïodice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V (Apr 2003). "The conserved Nup107-160 complex is critical for nuclear pore complex assembly". Cell. 113 (2): 195–206. doi:10.1016/S0092-8674(03)00235-6. PMID 12705868. 
  5. ^ a b "Entrez Gene: NUP107 nucleoporin 107kDa". 
  6. ^ Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587free to read. PMID 15146057. 
  7. ^ Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". The Journal of Cell Biology. 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC 2150808free to read. PMID 11564755. 

Further reading[edit]