Nucleoporin 107

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Protein NUP107 PDB 3CQC.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases NUP107, NUP84, NPHS11, nucleoporin 107kDa, nucleoporin 107
External IDs MGI: 2143854 HomoloGene: 5555 GeneCards: NUP107
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for NUP107
Genomic location for NUP107
Band 12q15 Start 68,686,734 bp[1]
End 68,745,809 bp[1]
RNA expression pattern
PBB GE NUP107 218768 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 12: 68.69 – 68.75 Mb Chr 12: 117.75 – 117.79 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene.[5][6][7]


This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[7]


NUP107 has been shown to interact with NUP133.[8][9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111581 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052798 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Boehmer T, Enninga J, Dales S, Blobel G, Zhong H (Feb 2003). "Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex". Proceedings of the National Academy of Sciences of the United States of America. 100 (3): 981–5. doi:10.1073/pnas.252749899. PMC 298712Freely accessible. PMID 12552102. 
  6. ^ Walther TC, Alves A, Pickersgill H, Loïodice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V (Apr 2003). "The conserved Nup107-160 complex is critical for nuclear pore complex assembly". Cell. 113 (2): 195–206. doi:10.1016/S0092-8674(03)00235-6. PMID 12705868. 
  7. ^ a b "Entrez Gene: NUP107 nucleoporin 107kDa". 
  8. ^ Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587Freely accessible. PMID 15146057. 
  9. ^ Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". The Journal of Cell Biology. 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC 2150808Freely accessible. PMID 11564755. 

Further reading[edit]