Nucleoporin 133

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Nucleoporin 133kDa
Protein NUP133 PDB 1xks.png
PDB rendering based on 1xks.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NUP133 ; hNUP133
External IDs OMIM607613 MGI2442620 HomoloGene32402 GeneCards: NUP133 Gene
RNA expression pattern
PBB GE NUP133 202184 s at tn.png
More reference expression data
Species Human Mouse
Entrez 55746 234865
Ensembl ENSG00000069248 ENSMUSG00000039509
UniProt Q8WUM0 Q8R0G9
RefSeq (mRNA) NM_018230 NM_172288
RefSeq (protein) NP_060700 NP_758492
Location (UCSC) Chr 1:
229.44 – 229.51 Mb
Chr 8:
123.9 – 123.95 Mb
PubMed search [1] [2]

Nucleoporin 133 (Nup133) is a protein that in humans is encoded by the NUP133 gene.[1][2]


The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells.[2]


Nup133 has been shown to interact with NUP107.[3][4]


  1. ^ Vasu S, Shah S, Orjalo A, Park M, Fischer WH, Forbes DJ (Oct 2001). "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export". The Journal of Cell Biology 155 (3): 339–54. doi:10.1083/jcb.200108007. PMC 2150853. PMID 11684705. 
  2. ^ a b "Entrez Gene: NUP133 nucleoporin 133kDa". 
  3. ^ Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057. 
  4. ^ Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". The Journal of Cell Biology 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC 2150808. PMID 11564755. 

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