Nucleoporin 153

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NUP153
Protein NUP153 PDB 2gqe.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases NUP153, HN153, nucleoporin 153kDa
External IDs MGI: 2385621 HomoloGene: 68442 GeneCards: 9972
Genetically Related Diseases
Disease Name References
obesity
RNA expression pattern
PBB GE NUP153 202097 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278209
NM_001278210
NM_005124

NM_175749

RefSeq (protein)

NP_001265138.1
NP_001265139.1
NP_005115.2

n/a

Location (UCSC) Chr 6: 17.62 – 17.71 Mb Chr 13: 46.68 – 46.73 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and required for the achoring of NPCs. It also acts as the docking site of an importing karyopherin.[4] On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role.

Background[edit]

Main article: Nuclear pore

Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are pore complex-specific glycoproteins characterized by cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG.

Structure[edit]

Nucleoporin 153 has a mass of 153 kDA (hence its name). It is filamentous and it contains three distinct domains: a N-terminal region within which a pore targeting domain has been identified, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats.[5]

Interactions[edit]

NUP153 has been shown to interact with SENP2[6][7] and KPNB1.[8][9][10]

References[edit]

  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_9970&geneId=205555". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Moroianu J, Blobel G, Radu A (1997). "RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153.". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9699–704. doi:10.1073/pnas.94.18.9699. PMC 23253free to read. PMID 9275187. 
  5. ^ "Entrez Gene: NUP153 nucleoporin 153kDa". 
  6. ^ Hang, Jun; Dasso Mary (May 2002). "Association of the human SUMO-1 protease SENP2 with the nuclear pore". J. Biol. Chem. United States. 277 (22): 19961–6. doi:10.1074/jbc.M201799200. ISSN 0021-9258. PMID 11896061. 
  7. ^ Zhang, Hong; Saitoh Hisato; Matunis Michael J (September 2002). "Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex". Mol. Cell. Biol. United States. 22 (18): 6498–508. doi:10.1128/MCB.22.18.6498-6508.2002. ISSN 0270-7306. PMC 135644free to read. PMID 12192048. 
  8. ^ Nakielny, S; Shaikh S; Burke B; Dreyfuss G (April 1999). "Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain". EMBO J. ENGLAND. 18 (7): 1982–95. doi:10.1093/emboj/18.7.1982. ISSN 0261-4189. PMC 1171283free to read. PMID 10202161. 
  9. ^ Kehlenbach, R H; Gerace L (June 2000). "Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro". J. Biol. Chem. UNITED STATES. 275 (23): 17848–56. doi:10.1074/jbc.M001455200. ISSN 0021-9258. PMID 10749866. 
  10. ^ Ben-Efraim, I; Gerace L (January 2001). "Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import". J. Cell Biol. United States. 152 (2): 411–7. doi:10.1083/jcb.152.2.411. ISSN 0021-9525. PMC 2199621free to read. PMID 11266456. 

Further reading[edit]