Nucleoporin 85

From Wikipedia, the free encyclopedia
  (Redirected from NUP85)
Jump to: navigation, search
NUP85
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NUP85, Nup75, FROUNT, nucleoporin 85
External IDs MGI: 3046173 HomoloGene: 11755 GeneCards: NUP85
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for NUP85
Genomic location for NUP85
Band 17q25.1 Start 75,205,659 bp[1]
End 75,235,758 bp[1]
RNA expression pattern
PBB GE NUP85 218014 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303276
NM_024844
NM_001330472

NM_001002929

RefSeq (protein)

NP_001290205
NP_001317401
NP_079120

NP_001002929

Location (UCSC) Chr 17: 75.21 – 75.24 Mb Chr 11: 115.56 – 115.58 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nucleoporin 85 (Nup85) is a protein that in humans is encoded by the NUP85 gene.[5][6]

Function[edit]

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.[6]

Model organisms[edit]

Model organisms have been used in the study of NUP85 function. A conditional knockout mouse line called Nup85tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[7] Male and female animals underwent a standardized phenotypic screen[8] to determine the effects of deletion.[9][10][11][12] Additional screens performed: - In-depth immunological phenotyping[13]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125450 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020739 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Doxsey SJ, Stein P, Evans L, Calarco PD, Kirschner M (Feb 1994). "Pericentrin, a highly conserved centrosome protein involved in microtubule organization". Cell. 76 (4): 639–50. doi:10.1016/0092-8674(94)90504-5. PMID 8124707. 
  6. ^ a b "Entrez Gene: NUP85 nucleoporin 85kDa". 
  7. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  8. ^ a b "International Mouse Phenotyping Consortium". 
  9. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750. 
  10. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  11. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  12. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207Freely accessible. PMID 23870131. 
  13. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]