Nucleoporin 88

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NUP88
Identifiers
Aliases NUP88
External IDs MGI: 104900 HomoloGene: 1901 GeneCards: NUP88
RNA expression pattern
PBB GE NUP88 202900 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002532
NM_001320653

NM_001083331
NM_001276406
NM_172394

RefSeq (protein)

NP_001307582
NP_002523

Location (UCSC) Chr 17: 5.36 – 5.42 Mb Chr 11: 70.94 – 70.97 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene.[3][4]

Function[edit]

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias.[4]

Interactions[edit]

NUP88 has been shown to interact with NUP98.[5]

References[edit]

Further reading[edit]