NUTF2

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NUTF2
Protein NUTF2 PDB 1a2k.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NUTF2, NTF2, PP15, NTF-2, nuclear transport factor 2
External IDs MGI: 1915301 HomoloGene: 110745 GeneCards: NUTF2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005796
NM_001322038
NM_001322039
NM_001322040
NM_001322041

NM_026532

RefSeq (protein)

NP_080808.1
NP_080808

Location (UCSC) Chr 16: 67.85 – 67.87 Mb Chr 8: 105.86 – 105.88 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear transport factor 2 is a protein that in humans is encoded by the NUTF2 gene.[3][4][5]

Function[edit]

The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.[5]

Interactions[edit]

NUTF2 has been shown to interact with Nucleoporin 62[3]{[6] and RAN.[7][8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Paschal BM, Gerace L (Jun 1995). "Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62". J Cell Biol. 129 (4): 925–937. doi:10.1083/jcb.129.4.925. PMC 2120498Freely accessible. PMID 7744965. 
  4. ^ Grundmann U, Nerlich C, Rein T, Lottspeich F, Küpper HA (Jul 1988). "Isolation of cDNA coding for the placental protein 15 (PP15)". Nucleic Acids Res. 16 (10): 4721–4721. doi:10.1093/nar/16.10.4721. PMC 336660Freely accessible. PMID 3380696. 
  5. ^ a b "Entrez Gene: NUTF2 nuclear transport factor 2". 
  6. ^ Hu T, Guan T, Gerace L (Aug 1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945Freely accessible. PMID 8707840. 
  7. ^ Cushman I, Bowman BR, Sowa ME, Lichtarge O, Quiocho FA, Moore MS (Nov 2004). "Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2". J. Mol. Biol. 344 (2): 303–310. doi:10.1016/j.jmb.2004.09.043. PMID 15522285. 
  8. ^ Stewart M, Kent HM, McCoy AJ (Apr 1998). "Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran". J. Mol. Biol. 277 (3): 635–646. doi:10.1006/jmbi.1997.1602. PMID 9533885. 

Further reading[edit]

External links[edit]