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NWD1, short for NACHT and WD repeat domain containing 1, is a gene found in vertebrates, which encodes a protein that contains a NACHT domain and a WD40 repeat domain. It was originally identified during a search for immune system genes in zebrafish as a protein coding sequence related to APAF1; orthologs were subsequently identified in mammalian species.[1] The NWD1 gene of humans is located on chromosome 19. Current data suggests a causal role for tumor-associated over-expression of NWD1 in the dysregulation of androgen receptor signaling during prostate cancer progression.[2]


  1. ^ Stein C, Caccamo M, Laird G, Leptin M (2007). "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish". Genome Biol. 8 (11): R251. doi:10.1186/gb-2007-8-11-r251. PMC 2258186Freely accessible. PMID 18039395. 
  2. ^ Correa, R. G., Krajewska, M., Ware, C. F., Gerlic, M., & Reed, J. C. (2014). The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling. Oncotarget, 5(6), 1657–1665.

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