NXT1

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NXT1
Protein NXT1 PDB 1jkg.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NXT1, MTR2, P15, nuclear transport factor 2 like export factor 1
External IDs MGI: 1929619 HomoloGene: 8301 GeneCards: NXT1
RNA expression pattern
PBB GE NXT1 218708 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013248

NM_001110159
NM_019761

RefSeq (protein)

NP_037380

NP_001103629.1
NP_062735.4
NP_001103629
NP_062735

Location (UCSC) Chr 20: 23.35 – 23.35 Mb Chr 2: 148.67 – 148.68 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.[3][4][5]

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Black BE, Levesque L, Holaska JM, Wood TC, Paschal BM (Jan 2000). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Mol Cell Biol. 19 (12): 8616–24. PMC 84993Freely accessible. PMID 10567585. 
  4. ^ Guzik BW, Levesque L, Prasad S, Bor YC, Black BE, Paschal BM, Rekosh D, Hammarskjold ML (Mar 2001). "NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells". Mol Cell Biol. 21 (7): 2545–54. doi:10.1128/MCB.21.7.2545-2554.2001. PMC 86886Freely accessible. PMID 11259602. 
  5. ^ a b "Entrez Gene: NXT1 NTF2-like export factor 1". 

Further reading[edit]