Norbert Perrimon

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Norbert Perrimon
Born (1958-10-24) October 24, 1958 (age 59) [1]
Bosguérard-de-Marcouville [1]
Nationality France
Citizenship France, United States
Alma mater University of Paris
Known for GAL4/UAS system
Awards George W. Beadle Award (2004)[2]
Scientific career
Thesis Analyse Clonale de Mutations en Lignee Germinale chez la Drosophile (1983)
Academic advisors Madeleine Gans

Norbert Perrimon (born October 24, 1958) is a geneticist and developmental biologist at Harvard Medical School. He is known for developing a number of techniques for use of Drosophila, as well as specific substantive contributions to signal transduction and developmental biology. Perrimon co-developed the GAL4/UAS system method, described as “a fly geneticist's Swiss army knife”,[3] with Andrea Brand to control gene expression.[4] With Tze-bin Chou he developed the FLP-FRT DFS method to analyze the maternal effect of zygotic lethal mutations.[5][6][7] With Jianquan Ni, he developed and improved methods for in vivo RNAi.[8][9][10] His lab has pioneered high-throughput whole-genome RNAi screening.[11][12][13][14][15][16]

In 2003 he created the Drosophila RNAi Screening Center at Harvard Medical School and in 2008, he initiated the Transgenic RNAi Project to generate transgenic RNAi lines for the community using optimized shRNA vectors that his lab developed.


Perrimon was born in 1958 in Bosguérard-de-Marcouville, France. He earned his undergraduate degree (Maitrise of Biochemistry) at the University of Paris VI, in 1981, then completed his doctorate in 1983 with Madeleine Gans, also at the University of Paris.


From 1983 to 1986 Perrimon was a postdoctoral researcher with Anthony Mahowald[17][18][19][20] at Case Western Reserve University, and in 1986 at the age of 27 he accepted appointment as faculty at Harvard Medical School. He is currently the James Stillman Professor of Developmental Biology in the Department of Genetics at Harvard Medical School. He has been an Investigator of the Howard Hughes Medical Institute since 1986.[21]

Awards and honors[edit]

Perrimon was elected to the United States National Academy of Sciences in April 2013,[12][22] after naturalizing as an American citizen.


  1. ^ a b
  2. ^ a b Schüpbach, T. (2004). "The 2004 George W. Beadle Medal". Genetics. 166 (2): 649–650. doi:10.1534/genetics.166.2.649. PMC 1470725Freely accessible. PMID 15020455. 
  3. ^ Shetty, P. (2008). "Molecular biologist Andrea Brand: encouraging women in science". The Lancet. 371 (9617): 979–979. doi:10.1016/S0140-6736(08)60439-0. PMID 18358916. 
  4. ^ Brand, A. H.; Perrimon, N. (1993). "Targeted gene expression as a means of altering cell fates and generating dominant phenotypes". Development. 118 (2): 401–415. PMID 8223268. 
  5. ^ Chou, T. B.; Perrimon, N. (1992-07-01). "Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila". Genetics. 131 (3): 643–653. ISSN 0016-6731. PMC 1205036Freely accessible. PMID 1628809. 
  6. ^ Chou, T. B.; Noll, E.; Perrimon, N. (1993-12-01). "Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras". Development. 119 (4): 1359–1369. ISSN 0950-1991. PMID 8306893. 
  7. ^ Chou, Tze-bin; Perrimon, Norbert (1996-12-01). "The Autosomal FLP-DFS Technique for Generating Germline Mosaics in Drosophila melanogaster". Genetics. 144 (4): 1673–1679. ISSN 0016-6731. PMC 1207718Freely accessible. PMID 8978054. 
  8. ^ Ni, Jian-Quan; Markstein, Michele; Binari, Richard; Pfeiffer, Barret; Liu, Lu-Ping; Villalta, Christians; Booker, Matthew; Perkins, Lizabeth; Perrimon, Norbert (2008-01-01). "Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster". Nature Methods. 5 (1): 49–51. doi:10.1038/nmeth1146. ISSN 1548-7091. PMC 2290002Freely accessible. PMID 18084299. 
  9. ^ Ni, Jian-Quan; Liu, Lu-Ping; Binari, Richard; Hardy, Robert; Shim, Hye-Seok; Cavallaro, Amanda; Booker, Matthew; Pfeiffer, Barret D.; Markstein, Michele (2009-08-01). "A Drosophila resource of transgenic RNAi lines for neurogenetics". Genetics. 182 (4): 1089–1100. doi:10.1534/genetics.109.103630. ISSN 1943-2631. PMC 2728850Freely accessible. PMID 19487563. 
  10. ^ Ni, Jian-Quan; Zhou, Rui; Czech, Benjamin; Liu, Lu-Ping; Holderbaum, Laura; Yang-Zhou, Donghui; Shim, Hye-Seok; Tao, Rong; Handler, Dominik (2011-05-01). "A genome-scale shRNA resource for transgenic RNAi in Drosophila". Nature Methods. 8 (5): 405–407. doi:10.1038/nmeth.1592. ISSN 1548-7105. PMC 3489273Freely accessible. PMID 21460824. 
  11. ^ Perrimon, N. (2005). "Norbert Perrimon". Current Biology. 15 (13): R481–R482. doi:10.1016/j.cub.2005.06.050. PMID 16059997. 
  12. ^ a b Ravindran, S (2014). "Profile of Norbert Perrimon". Proceedings of the National Academy of Sciences. 111 (21): 7501–2. doi:10.1073/pnas.1406464111. PMC 4040556Freely accessible. PMID 24778217. 
  13. ^ Perrimon, N; Gans, M (1983). "Clonal analysis of the tissue specificity of recessive female-sterile mutations of Drosophila melanogaster using a dominant female-sterile mutation Fs(1)K1237". Developmental Biology. 100 (2): 365–73. doi:10.1016/0012-1606(83)90231-2. PMID 6418585. 
  14. ^ Perrimon, N (1984). "Clonal Analysis of Dominant Female-Sterile, Germline-Dependent Mutations in DROSOPHILA MELANOGASTER". Genetics. 108 (4): 927–39. PMC 1224274Freely accessible. PMID 17246244. 
  15. ^ White, R. A.; Perrimon, N; Gehring, W. J. (1984). "Differentiation markers in the Drosophila ovary". Journal of Embryology and Experimental Morphology. 84: 275–86. PMID 6442733. 
  16. ^ Perrimon, N.; Engstrom, L.; Mahowald, A. P. (1984). "The effects of zygotic lethal mutations on female germ-line functions in Drosophila". Developmental Biology. 105 (2): 404–414. doi:10.1016/0012-1606(84)90297-5. 
  17. ^ Perrimon, N; Engstrom, L; Mahowald, A. P. (1985). "Developmental genetics of the 2C-D region of the Drosophila X chromosome". Genetics. 111 (1): 23–41. PMC 1202596Freely accessible. PMID 3928431. 
  18. ^ Perrimon, N; Mohler, D; Engstrom, L; Mahowald, A. P. (1986). "X-linked female-sterile loci in Drosophila melanogaster". Genetics. 113 (3): 695–712. PMC 1202863Freely accessible. PMID 3089870. 
  19. ^ Perrimon, N; Mahowald, A. P. (1986). "L(1)hopscotch, A larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila". Developmental Biology. 118 (1): 28–41. doi:10.1016/0012-1606(86)90070-9. PMID 3095163. 
  20. ^ Perrimon, N; Mahowald, A. P. (1987). "Multiple functions of segment polarity genes in Drosophila". Developmental Biology. 119 (2): 587–600. doi:10.1016/0012-1606(87)90061-3. PMID 3803719. 
  21. ^ "Norbert Perrimon, PhD |". Retrieved 2016-11-21. 
  22. ^ "April 30, 2013, NAS Election", National Academy of Sciences (last visited May 3, 2013).
  23. ^ "Innovator Award Recipients". GeneExpression Systems. Retrieved 31 October 2016.