He is from a noted family of the Gondal, Dist.Rajkot, Gujarat. His father, Mansingh Chudasama, was police commissioner. Nana was second of three brothers, his elder brother the late Mota Chudasama being a noted businessman, and his younger brother Chota being associated with Air India for many years. Nana after graduation started his career in the early 1950s as an executive in a US petroleum company in Mumbai; he also managed an apartment at Prithviraj Chambers, on Narayan Dabholkar Road in the elite Nepean Sea Road area, next door to where he lived at the time.
In his later career, Nana became the founder of the NGO Giants International which has over 500 branches in India and branches across the world including the United States, United Kingdom, South Africa, Mauritius and Ukraine. Giants undertakes projects which affect society, such as family welfare, disaster management, education, environment and so on.
Chudasama is also the president of "I Love Mumbai" which he founded when he was Sheriff of Mumbai. The organization focuses on the greening, beautification and cleaning of Mumbai. He is also the President of Forum Against Drugs and AIDS which he founded, chairperson of the National Kidney Foundation, Founder President of Common Man's Forum, an organization to safeguard the interests of the common man; Convener, Relief and Rehabilitation Committee, Government of Maharashtra, which assists bomb blast victims. He was also the national president of Jaycees, which had earlier awarded him the Young Man of India Award; former president of Indo-American Society. He is also a member of the Task Force of the Government of Maharashtra to prepare action plan for transforming Mumbai into a better city.