From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

Nanoimpellers are an experimental technology developed to eliminate some of the harmful effects of chemotherapy by facilitating treatment of only specific areas of the body. Nanoimpellers are nanoscale, light-activated containers filled with cancer-fighting drugs that only release their contents when hit by a specific type of laser.[1]

Nanoimpellers for cancer drug delivery were first demonstrated in 2008.[2][3] Initial work used ultraviolet light, however the low penetration in tissue and potential for toxicity mean this is not well suited for delivery in patients.[1] Later work has shifted to using near infrared light and two photon excitation (TPE) to trigger release.[4][5]

See also[edit]


  1. ^ a b Zheng, Yue Bing; Kiraly, Brian; Huang, Tony Jun (November 2010). "Molecular machines drive smart drug delivery". Nanomedicine. 5 (9): 1309–1312. doi:10.2217/nnm.10.111Freely accessible. PMID 21128714. 
  2. ^ Lu, Jie; Choi, Eunshil; Tamanoi, Fuyuhiko; Zink, Jeffrey I. (31 March 2008). "Light-Activated Nanoimpeller-Controlled Drug Release in Cancer Cells". Small. 4 (4): 421–426. doi:10.1002/smll.200700903. PMC 2712492Freely accessible. PMID 18383576. 
  3. ^ "Nanomachine Kills Cancer Cells With Exposure To Light". Inventorspot. 25 April 2008. Retrieved 30 March 2015. 
  4. ^ Tian, He; Zhang, Junji. Photochromic Materials: Preparation, Properties and Applications. John Wiley & Sons. p. 223. ISBN 9783527683703. 
  5. ^ Croissant, Jonas; Maynadier, Marie; Gallud, Audrey; Peindy N'Dongo, Harmel; Nyalosaso, Jeff L.; Derrien, Gaëlle; Charnay, Clarence; Durand, Jean-Olivier; Raehm, Laurence; Serein-Spirau, Françoise; Cheminet, Nathalie; Jarrosson, Thibaut; Mongin, Olivier; Blanchard-Desce, Mireille; Gary-Bobo, Magali; Garcia, Marcel; Lu, Jie; Tamanoi, Fuyuhiko; Tarn, Derrick; Guardado-Alvarez, Tania M.; Zink, Jeffrey I. (16 December 2013). "Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers". Angewandte Chemie International Edition. 52 (51): 13813–13817. doi:10.1002/anie.201308647. PMC 3940420Freely accessible. 

External links[edit]