Natalie Strynadka

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Natalie Strynadka
FRS
Professor Natalie C. J. Strynadka FRS.jpg
Natalie Strynadka at the Royal Society admissions day in London, July 2015
BornNatalie C. J. Strynadka
1963 (age 54–55)[1]
Alma materUniversity of Alberta (BSc, PhD)
Awards
Scientific career
Fields
Institutions
ThesisProbing molecular interactions at various levels of structural definition (1990)
Doctoral advisorMichael N. G. James[7]
Website

Natalie C. J. Strynadka FRS[2] is a professor[8][9] of Biochemistry in the Department of Biochemistry and Molecular Biology at the University of British Columbia.[10][11][12][13][14]

Education[edit]

Strynadka was educated at the University of Alberta where she was awarded a PhD in 1990.[15] Her thesis committee included Michael N. G. James and Sir David Chilton Phillips.[15]

Awards and honours[edit]

Strynadka was elected a Fellow of the Royal Society (FRS) in 2015. Her certificate of election reads:[2]

Natalie Strynadka is a pioneer in the study of proteins and protein assemblies essential to bacterial pathogenicity and antibiotic resistance. Her agenda-setting dissection of the membrane assemblies involved in infection, virulence and bacterial cell wall synthesis is having major impact in the development of therapeutic agents; both antibiotics and vaccines.

References[edit]

  1. ^ Natalie Strynadka VIAF 105554096
  2. ^ a b c Anon (2015). "Professor Natalie Strynadka FRS". London: royalsociety.org. Archived from the original on 2015-05-12.
  3. ^ Lovering, A. L.; De Castro, L. H.; Lim, D; Strynadka, N. C. (2007). "Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis". Science. 315 (5817): 1402–5. doi:10.1126/science.1136611. PMID 17347437.
  4. ^ Wilke, M. S.; Heller, M; Creagh, A. L.; Haynes, C. A.; McIntosh, L. P.; Poole, K; Strynadka, N. C. (2008). "The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR". Proceedings of the National Academy of Sciences. 105 (39): 14832–7. doi:10.1073/pnas.0805489105. PMC 2567453. PMID 18812515.
  5. ^ Strynadka, N. C.; Jensen, S. E.; Johns, K; Blanchard, H; Page, M; Matagne, A; Frère, J. M.; James, M. N. (1994). "Structural and kinetic characterization of a beta-lactamase-inhibitor protein". Nature. 368 (6472): 657–60. doi:10.1038/368657a0. PMID 8145854.
  6. ^ King, A. M.; Reid-Yu, S. A.; Wang, W; King, D. T.; De Pascale, G; Strynadka, N. C.; Walsh, T. R.; Coombes, B. K.; Wright, G. D. (2014). "Aspergillomarasmine a overcomes metallo-β-lactamase antibiotic resistance". Nature. 510 (7506): 503–6. doi:10.1038/nature13445. PMC 4981499. PMID 24965651.
  7. ^ Strynadka, N. C. J.; James, M. N. G. (1989). "Crystal Structures of the Helix-Loop-Helix Calcium-Binding Proteins". Annual Review of Biochemistry. 58: 951–98. doi:10.1146/annurev.bi.58.070189.004511. PMID 2673026.
  8. ^ "Strynadka laboratory". strynadkalab.biochem.ubc.ca. Archived from the original on 2015-08-12.
  9. ^ "Natalie C.J. Strynadka, PhD: Senior International Research Scholar / 2012–Present". hhmi.org. Archived from the original on 2015-05-18.
  10. ^ Strynadka, N. C.; Adachi, H; Jensen, S. E.; Johns, K; Sielecki, A; Betzel, C; Sutoh, K; James, M. N. (1992). "Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 a resolution". Nature. 359 (6397): 700–5. doi:10.1038/359700a0. PMID 1436034.
  11. ^ Paetzel, M; Karla, A; Strynadka, N. C.; Dalbey, R. E. (2002). "Signal peptidases". Chemical Reviews. 102 (12): 4549–80. doi:10.1021/cr010166y. PMID 12475201.
  12. ^ Gao, S; Kinzig, K. P.; Aja, S; Scott, K. A.; Keung, W; Kelly, S; Strynadka, K; Chohnan, S; Smith, W. W.; Tamashiro, K. L.; Ladenheim, E. E.; Ronnett, G. V.; Tu, Y; Birnbaum, M. J.; Lopaschuk, G. D.; Moran, T. H. (2007). "Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake". Proceedings of the National Academy of Sciences. 104 (44): 17358–63. doi:10.1073/pnas.0708385104. PMC 2077261. PMID 17956983.
  13. ^ Zarivach, R; Deng, W; Vuckovic, M; Felise, H. B.; Nguyen, H. V.; Miller, S. I.; Finlay, B. B.; Strynadka, N. C. (2008). "Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS". Nature. 453 (7191): 124–7. doi:10.1038/nature06832. PMID 18451864.
  14. ^ Natalie Strynadka publications indexed by the Scopus bibliographic database. (subscription required)
  15. ^ a b Strynadka, Natalie C. J. (1990). Probing molecular interactions at various levels of structural definition (PhD thesis). University of Alberta. doi:10.7939/R37D2QG6S. OCLC 70312424. open access publication – free to read