She was born in Yaroslavl, but represented the club Grodno TU. She competed at the 1993 and 1995 World Championships without reaching the final. Her career peaked in the year 1994. She became European indoor champion in 1994, and in the same year she won the silver medal at the European Championships. She also finished third at the 1994 IAAF World Cup.
She finished seventh in her special event 800 metres at the 1996 Olympic Games, and also competed in the 1500 metres without reaching the final. She returned with a silver medal at the 1997 World Indoor Championships, a seventh place at the 1998 European Championships and an eighth place at the 1999 World Championships. She also won a bronze medal at the 1995 Military World Games and silver medal at the 1999 Military World Games.
However, she often failed to reach the final in large events. She reached the semi-final at the 1997 World Championships and 1999 World Indoor Championships, and only round one at the 2000 Olympic Games and the 2001 World Championships.
Her personal best times were 1:57.24 minutes in the 800 metres, achieved in June 1996 in Gomel; 4:06.70 minutes in the 1500 metres, achieved in June 1997 in Saint-Denis; and 4:37.35 minutes in the mile run, achieved in July 1997 in Lausanne.
- "Natasha Dukhnova". Sports-Reference.com. Retrieved 25 May 2014.
- Natalya Dukhnova at IAAF
- "European Indoor Championships (Women)". GBR Athletics. Athletics Weekly. Retrieved 25 May 2014.
- "European Championships (Women)". GBR Athletics. Athletics Weekly. Retrieved 25 May 2014.
- "IAAF World Cup in Athletics". GBR Athletics. Athletics Weekly. Retrieved 25 May 2014.
- "Women 800m European Championships 1998 Budapest (HUN)". Todor Krastev. Retrieved 25 May 2014.
- "CISM Military World Games". GBR Athletics. Athletics Weekly. Retrieved 25 May 2014.