The work has eight books, though parts of Books 4a and 4b are now lost.
The original order of the books is a matter of scholarly disagreement (c.f. Limburg p. 10-11 & M von Albrecht). Several scholars consider an order, which is for example proposed by HM Hines (c.f. Tracey p. 249), being Book 3 (firstly), then Book 4a, 4b, Books 5-7 then Books 1, and finally Book 2, to be the true order.
For Seneca, behaving with morality was the ultimate aim of life,so the very possibility of virtue in a human was dependent on a person behaving in a way accordant to nature. The highest good or virtue: secundum naturam suam vivere in Ep 41:9, Ep 121:3 (c.f. - p. 84 for English translation); naturam here refers to both nature in general and one's own innate nature.
In Naturales quaestiones Seneca refers to the name of Nero (on four occasions - c.f. - p. 246) in whose reign Seneca belonged.Specifically in regards to this, Tracey identifies in his work (p. 251), an example of a moral message within the study, vis-à-vis lightening bolts (Book 2.43), on the subject of the moral conduct of an absolute monarch. Seneca thought an effort of promoting an active interest in science to Nero, would be beneficial to the emperor's morality (p. 249 - here also quoting H Hine 2006).
What is most important? Not to admit bad intentions into your mind, to raise pure hands to heaven...to raise your spirits high above chance occurrences .... for these reasons the study of nature will be helpful.....we shall leave behind what is sordid.... separate the mind, which needs to be elevated and great, from the body ... when we have exercised our intellect on hidden obscurities, it will be no less effective on matters in plain view— - NQ3 Preface
[Quote taken from GD Williams p. 1-2 ]
Contemplation of nature for Seneca unchains the mind (quote from Bjornlie of Corcoran translation) enabling a person to transcend evil, and by experiencing the totum  of nature, develop a consciousness and being more compatible with direct experience of God, by elevating one's moral. (p. 3 of Williams and 260 of Bjornlie show different translations of the same passage in relation to this).
quisquis formator universi fuit sive ille Deus est portens omnium, sive incorporalis ratio,ingentium operum artifex, sive divinus spiritus, per omnia, maxima, minima, aequali intentione diffusus 
The achievement of an existence in keeping with the correct manner of living, that is being ethical, depended on a person fulfilling that existence in accordance with the principles of the ius naturae (p.258 ), of the divine universal order lex universi (Seneca - Ep 76.23 as shown at p.84-5 ), inherent in the totum of nature. To make one in agreement with nature (όμολογουμένως τή φύσει). 
Stoics from early in their tenet of thought considered the telos of their efforts to be kata physin.  The participation of the faculty of reason within the divine order stems in the least from Platonic thought. 
|“||I am not unaware, Lucilius, excellent man, of how great is the enterprise whose foundations I am laying in my old age, now that I have decided to traverse the world, to seek out its causes and secrets, and to present them for others to learn about. [Book 3] ||”|
It is one of the few Roman works which deals with scientific matters. It is not a systematic work, but a collection of facts of nature from various writers, Greek and Roman, many of which are curiosities. Moral remarks are scattered through the work; and indeed the design of the whole appears to be to find a foundation for ethics in the knowledge of nature.
The following numbers correspond to each book, and to the natural phenomenon dealt with by the author in that book:
5 - winds.
7 - comets.
Relevant modern thought
cosmic religious feeling
- J Tracy cross references Hine (2006) for this on p.104 - footnote 9 [Retrieved 2015-3-18]
- GD Williams. The Cosmic Viewpoint: A Study of Seneca's 'Natural Questions'. Oxford University Press, 8 Mar 2012 ISBN 0199742510. Retrieved 2015-03-17.
- Oxford Dictionaries - conventional Oxford University Press [Retrieved 2015-3-18]
- HM Hine - Studies in the Text of Seneca's "Naturales Quaestiones" - Bibliography (Walter de Gruyter, 1 Jan 1996) ISBN 3110958074 [Retrieved 2015-3-16]
- Harold B.Lee Library - BSC Latin place names [Retrieved 2015-3-16]
- Oxford Dictionaries [Retrieved 2015-3-16]
- M von Albrecht - A History of Roman Literature: From Livius Andronicus to Boethius : with Special Regard to Its Influence on World Literature (p.1193) Editor GL Schmeling (BRILL, 1997) ISBN 9004107118 [Retrieved 2015-3-17]
- J Sperna Weiland, W Th. M. Frijhoff - Erasmus of Rotterdam: The Man and the Scholar : Proceedings of the Symposium Held at the Erasmus University, Rotterdam, 9-11 November 1986, Volumes 9-11 (p.159) (Brill Archive, 1988) ISBN 9004089209[Retrieved 2015-3-17]
- edited by Charles Knight - Biography: Or, Third Division of "The English Encyclopedia", Volume 1 (Bradbury, Evans & Company, 1866) (copy originally from the University of Wisconsin - Madison)[Retrieved 2015-3-17]
- Limburg, F.J.G., 2007, Doctoral thesis, Leiden University
- Open Library at The Internet Archive - (shows) Table of Contents of Natural questions translated by Harry M. Hine Chicago : University of Chicago Press, 2010 ISBN 0226748383 [Retrieved 2015-3-16]
- OCLC WorldCat - for the following reference (i.e. DialABookServlet) choose <preview this item> from this link DialABookServlet [Retrieved 2015-3-16]
- Jonathan Tracy. Lucan's Egyptian Civil War. Cambridge University Press, 22 Sep 2014 ISBN 1107072077. Retrieved 2015-03-17.
- J Sellars - Stoicism (Routledge, 5 Dec 2014) ISBN 1317493915 [Retrieved 2015-3-16]
- WorldCat[Retrieved 2015-3-16]
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- Groenendijk, Leendert F. and de Ruyter, Doret J.(2009). 'Learning from Seneca: a Stoic perspective on the art of living and education', Ethics and Education (PDF). pp. 81 — 92. doi:10.1080/17449640902816277. Retrieved 2015-03-17.
- J Lovelock - Gaia : a new look at life on earth Oxford ; New York : Oxford University Press, 2000 [retrieved 2015-3-18] (ed. this work provided relevance of conceptual connection to Gaia (mythology) link within this article,and earlier concept of nature (ed.) as a single unified whole] (c.f. also Gaia hypothesis)
- MS Bjornlie. Politics and Tradition Between Rome, Ravenna and Constantinople: A Study of Cassiodorus and the Variae, 527-554. Cambridge University Press, 2013 ISBN 110702840X. Retrieved 2015-03-18.
- D Harper - etymonline : moral[Retrieved 2015-3-18]
- M Vassányi - Bayle's identification of Spinozism with the World-Soul theory (3rd paragraph of p.219) in Anima Mundi: The Rise of the World Soul Theory in Modern German Philosophy: The Rise of the World Soul Theory in Modern German Philosophy (Springer Science & Business Media, 16 Nov 2010) ISBN 9048187966 (Volume 202 of International Archives of the History of Ideas) [Retrieved 2015-3-18]
- Cambridge Dictionaries Online - - mundane (Cambridge University Press 2015)[Retrieved 2015-3-18]
- Oxford Dictionaries : intra- (Oxford University Press) [Retrieved 2015-3-18]
- G Reydams-Schils - Seneca's Platonism (in) Ancient Models of Mind: Studies in Human and Divine Rationality (p.205) (edited by A Nightingale - Professor of Classics and Comparative Literature at Stanford University, D Sedley - Laurence Professor of Ancient Philosophy at the University of Cambridge) Cambridge University Press, 11 Nov 2010 ISBN 1139489763[Retrieved 2015-3-18] (ed. source of initial Latin quisquis formator universi fuit - the Basore translation p.205 was of no direct influence in the additions here (and below), as I just so happened to have read it only after 18:33hrs)
- M. Shane Bjornlie c.f. particularly p.258 passage concerning Aristotle [Retrieved 2015-3-18]
- R Lynam - The British Essayists: Lucubrations, or Winter evenings. General index (p.94) J. F. Dove, 1827 (original copy from Harvard University)[Retrieved 2015-3-18] (ed. this reference provides an english language translation)
- Perseus Tufts Latin Word Study Tool - omnia [Retrieved 2015-3-18]
- Perseus Tufts Latin Word Study Tool - ius[Retrieved 2015-3-18]
- [Hirai, Hiro. "The World-Soul, Providence and Eschatology: Seneca’s Naturales Quaestiones in Justus Lipsius’s Physiologia Stoicorum." Seneca e le scienze.] google scholar search page showing title only [Retrieved 2015-3-16]
- J Wildberger - Brill's Companion to Seneca: Philosopher and Dramatist (p.315) Brill's Companions in Classical Studies (edited by Andreas Heil, Gregor Damschen) BRILL, 13 Dec 2013 ISBN 9004217088 [Retrieved 2015-3-18]
- D Mehl. The Stoic Paradoxes according to Cicero (in) Vertis in Usum p.40- edited by C Damon, JF Miller, KS Myers. Walter de Gruyter, 2002 ISBN 3598777108. Retrieved 2015-03-19.
- (edited by KR Bartlett) - The Civilization of the Italian Renaissance: A Sourcebook (p.98 left column of text - 2nd paragraph) University of Toronto Press, 2011 ISBN 1442604859 [Retrieved 2015-3-20]
- George Long (ed.William Smith). Seneca, L. Annaeus. Little, Brown and Company Boston 1867. Retrieved 2011-10-21.
- HM Hine (translator) On Terrestrial Waters Chicago : University of Chicago Press, 2010. [Retrieved 2015-3-17](ed. please go to <Preview this Item> to find this quote
- Posidonius, Ian Gray Kidd - Posidonius: The commentary. Vol.2 (p.503) (Cambridge University Press, 1988) ISBN 0521354994 [Retrieved 2015-3-18]
- Ian Gray Kidd - p.510 [Retrieved 2015-3-18]
- R Hoffmann, I Boyd Whyte - Beyond the Finite: The Sublime in Art and Science (p.122) ISBN 0199792747 (Oxford University Press, 14 Sep 2011) [Retrieved 2015-3-18]
- Long, George (1867). "Seneca, L. Annaeus". In William Smith. Dictionary of Greek and Roman Biography and Mythology 3. Boston: Little, Brown and Company. p. 782.
- Seneca, Naturales Quaestiones: Bks. I-III, v. 1. Loeb Classical Library
- Seneca, Naturales Quaestiones: Bks. IV-VII, v. 2. Loeb Classical Library
- Seneca, "Ricerche sulla Natura", a cura di Piergiorgio Parroni, Arnoldo Mondadori Editore, a recent (2010) edition with a fine comment.
- Latin Wikisource has original text related to this article: Quaestiones Naturales
- Naturales Quaestiones web texts
- Physical science in the time of Nero; being a translation of the Quaestiones naturales of Seneca, (1910). Translated by John Clarke, with notes by Archibald Geikie, at the Internet Archive.