Nebraska Highway 43 (N-43) is a highway in southeastern Nebraska. It runs for a length of 30 miles (48 km) in a south-to-north direction. Its southern terminus is near Adams at an intersection with N-41. Its northern terminus is at an intersection with U.S. Highway 34 (US 34) in Eagle.
Nebraska Highway 43 begins near Adams at an intersection with N-41. The highway heads due north into farmland until Bennet. Shortly after Bennet, the highway meets N-2. N-2 and N-43 overlap until Palmyra, which is where N-43 turns north. N-43 goes north for four miles (6 km), west for one, and then north for three more miles, where it meets US 34 in Eagle and ends.