Negative regulatory element

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A Negative regulatory element (NRE) is a sequence of DNA that represses the expression of certain genes,[1] for example that of the insulin gene.[2]


  1. ^ Hampsey, Michael. "Negative Regulatory Elements (NREs)". eLS. doi:10.1002/9780470015902.a0005030.pub2. 
  2. ^ Melloul et al., Diabetologica, 45, 309-326, year 2002. Regulation of insulin gene transcription