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Neoptolemus may refer to:
- Neoptolemus, son of Achilles and Deidamia in Greek mythology
- Neoptolemus (general) (died 321), general of Alexander the Great
- Neoptolemus I of Epirus, king of Epirus, son of Alcetas I, father of Alexander I of Epirus and Olympias, grandfather of Alexander the Great
- Neoptolemus II of Epirus, king of Epirus, nephew of Alexander the Great
- Neoptolemus (Pontic general), general of King Mithridates VI of Pontus
- Neoptolemus of Paros, Ancient Greek author
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