The source of the river lies north of the Christmas Mountains, in the rugged terrain between Mount Carleton, and Big Bald Mountain. Several falls are present along the river's course, including Indian Falls (near Popple Depot), Nepisiguit Falls and Pabineau Falls. Along this river lies a vast forest, where many individuals from New Brunswick set up camps. Lodges are set up along the river including Governors Lodge, Rogers Lake Lodge and many others. These lodges play host to the many individuals taking part in several different outdoor activities including hunting, fishing and snowmobiling along the river.
The Nepisiguit River is known for its fishing. Fishing along the Nepisiguit consists of Atlantic Salmon fishing as well as other fishing types including trout. Hunting is also another activity that takes part along the Nepisiguit because the significant animal population and various species within this region afford it. Some of the animals hunted along the Nepisiguit River include moose, deer, ruffed grouse and spruce grouse
The Nepisiguit River and surrounding area also have some of the best snowmobiling trails. During the winter months, individuals from around New Brunswick as well as other parts of Canada come to the Nepisiguit region to take part and join in the snowmobiling community.
The river is followed for much of its length by the Nepisiguit Mi'gmaq Trail, a hiking and backpacking trail that opened in 2018, retracing an ancient trail and portage route along the river.
William Francis Ganong remarked that, in his day, the Nepisiguit was the most remarkable river for fishing and hunting.
In 1981, the NSA partnered with Fisheries and Oceans Canada in a yearly summer programme to restock the salmon population. By 1988, five thousand salmon populated the river, in contrast to hundreds before the programme was started. From 1981 to 1993, over $1.5 million in funding was secured. By the 2000s, volunteers with the programme were awarded significant prizes.
In the years prior to 2017, volunteers placed a hundred thousand salmon fry per annum in the river as part of the restocking programme. Each September, volunteers begin selecting the largest as broodstock destined for the Charlo hatchery where eggs are collected and fertilized. The tiny alevins are placed, once hatched, in protective incubation boxes above and below Nepisiguit Falls. They are released into the river once they have reached the fry stage in their life cycle.
MacMillan, G. (1988).The Nepisiguit (River, New Brunswick). The Atlantic Advocate
- Rayburn, A. (1975) Geographical Names of New Brunswick. Toponymy Study 2. Surveys and Mapping Branch, Energy Mines and Resources Canada, Ottawa
- Geographical Names of Canada "Archived copy". Archived from the original on 2009-02-07. Retrieved 2009-02-07.CS1 maint: archived copy as title (link)
- The Northern Light, "Former salmon association president reflects on saving the Nepisiguit's salmon", 24 March 2017
- flyfishingnb.com: "Robert Wesley Baker"
- saltscapes.com: "Conserving Endangered Wild Salmon"
- Interactive map rncan.gc.ca: "Nepisiguit River (Formerly Nipisiguit River)"
- Media related to Rivière Népisiguit at Wikimedia Commons