Nervonic acid

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Nervonic acid[1]
Nervonic acid.png
Names
IUPAC name
(Z)-Tetracos-15-enoic acid
Other names
cis-15-Tetracosenoic acid
24:1 cis, delta 15 or 24:1 omega 9
Identifiers
506-37-6 N
ChEBI CHEBI:44247 YesY
ChEMBL ChEMBL1173379 YesY
ChemSpider 4444565 YesY
Jmol-3D images Image
KEGG C08323 YesY
PubChem 5281120
Properties
C24H46O2
Molar mass 366.62 g/mol
Melting point 42 to 43 °C (108 to 109 °F; 315 to 316 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Nervonic acid is a monounsaturated omega-9 fatty acid. Nervonic acid has been identified as important in the biosynthesis of nerve cell myelin.[2] It is found in the sphingolipids of white matter in human brain.

Nervonic acid is used in the treatment of disorders involving demyelination, such as adrenoleukodystrophy and multiple sclerosis where there is a decreased level of nervonic acid in sphingolipids.[3]

Dietary sources[edit]

Nervonic acid is abundant in king salmon (a.k.a. Chinook salmon) with 140 mg/100g, yellow mustard seed (83 mg/100g), flaxseed (64 mg/100g), sockeye salmon (40 mg/100g), sesame seed (35 mg/100g), and macadamia nuts (18 mg/100g). [4]

References[edit]

  1. ^ Nervonic acid at Sigma-Aldrich
  2. ^ US Patent 6664406, Nervonic acid derivatives, their preparation and use
  3. ^ WO/1996/005740, Nervonic Acid Compositions
  4. ^ http://nutritiondata.self.com/foods-000046000000000000000-w.html

Additional references[edit]

  • Appelqvist (1976) Lipids in Cruciferae. In: Vaughan JG, Macleod AJ (Eds), The biology and the Chemistry of Cruciferae. Academic Press, London, UK, pp. 221-277.
  • Sargent JR, Coupland K, Wilson R (1994). Nervonic Acid and Demyelinating Disease. Medical Hypothesese 42, pp. 237-242.