Nessus may refer to:
- Nessus (mythology), a famous centaur from Greek mythology
- Nessus, an alternate name of Nestos (god), son of Oceanus and Tethys, and god of the river Nestos
- Nessus (Pierson's Puppeteer), an alien character in Larry Niven's Known Space books
- Nessus, a fictional metropolis in Gene Wolfe's The Book of the New Sun
- Nessus, a layer of Hell in the Dungeons & Dragons game Baator
- Nessus, one of the moons of the fictional planet Chiron in the computer game Sid Meier's Alpha Centauri
- Nessus, a planetoid location in the video game Destiny 2, based on the below Centaur
Science and technology
- 7066 Nessus, a Centaur planetoid
- Nessus (software), a computer security tool
- Nessus (Blackberry), the proprietary kernel all Blackberry before BlackBerry 10 were based upon
- NESSUS Probabilistic Analysis Software, a tool for assessing uncertainties in structural and mechanical systems
- HMS Nessus, two vessels of the Royal Navy (UK)
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