Nettlecombe is a farming hamlet on the Isle of Wight. It is the site of a deserted medieval village and there is evidence of earthworks close to the present hamlet. There are several fishing lakes in Nettlecombe.
It is roughly centered on the corner of High Street and Nettlecombe Lane, about half a mile north of Whitwell. Until 1952, the Isle of Wight Central Railway had a station on Nettlecombe Lane.