Neuregulin 3

For the stimulant, see NRG-3.

NRG3
Identifiers
Aliases	NRG3, HRG3, pro-neuregulin 3
External IDs	OMIM: 605533 MGI: 1097165 HomoloGene: 32051 GeneCards: NRG3
Gene location (Human) Chr. Chromosome 10 (human) Band 10q23.1 Start 81,875,194 bp End 82,987,179 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 B Start 38,090,909 bp End 39,195,045 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell middle temporal gyrus Brodmann area 23 prefrontal cortex dorsolateral prefrontal cortex Brodmann area 9 cingulate gyrus superior frontal gyrus entorhinal cortex amygdala Top expressed in barrel cortex supraoptic nucleus Region I of hippocampus proper superior frontal gyrus substantia nigra medial geniculate nucleus trigeminal ganglion subiculum medial dorsal nucleus prefrontal cortex More reference expression data BioGPS n/a
Gene ontology Molecular function receptor tyrosine kinase binding growth factor activity transmembrane receptor protein tyrosine kinase activator activity chemorepellent activity signaling receptor binding Cellular component integral component of membrane extracellular region plasma membrane integral component of plasma membrane intracellular anatomical structure membrane extracellular space glutamatergic synapse Biological process pattern specification process mammary placode formation chemorepulsion involved in interneuron migration from the subpallium to the cortex negative regulation of neuron migration regulation of cell growth mammary gland development activation of transmembrane receptor protein tyrosine kinase activity intracellular signal transduction animal organ development regulation of signaling receptor activity nervous system development modulation of chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10718 18183 Ensembl ENSG00000185737 ENSMUSG00000041014 UniProt P56975 O35181 RefSeq (mRNA) NM_001010848 NM_001165972 NM_001165973 NM_001370081 NM_001370082 NM_001370083 NM_001370084 NM_001190187 NM_001190188 NM_008734 RefSeq (protein) NP_001010848 NP_001159444 NP_001159445 NP_001357010 NP_001357011 NP_001357012 NP_001357013 NP_001177116 NP_001177117 NP_032760 Location (UCSC) Chr 10: 81.88 – 82.99 Mb Chr 14: 38.09 – 39.2 Mb PubMed search
Wikidata
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Neuregulin 3 also known as NRG3 is a member of the neuregulin protein family which in humans is encoded by the NRG3 gene.

Function

NRG3 can bind to the extracellular domain of the ERBB4 receptor tyrosine kinase but not to the related family members ERBB2 or ERBB3. NRG3 binding stimulates tyrosine phosphorylation of ERBB4.

Clinical significance

Variants of the NRG3 gene have been linked to a susceptibility to schizophrenia.

It has also been linked to Hirschsprung's disease.

Further reading

• Benzel I, Bansal A, Browning BL, et al. (2007). "Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia". Behavioral and Brain Functions. 3 (1): 31. doi:10.1186/1744-9081-3-31. PMC 1934910. PMID 17598910.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Iijima M, Tomita M, Morozumi S, et al. (2009). "Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP". Neurology. 73 (17): 1348–52. doi:10.1212/WNL.0b013e3181bd1139. PMID 19776380.
• Shrestha S, Irvin MR, Taylor KD, et al. (2010). "A genome-wide association study of carotid atherosclerosis in HIV-infected men". AIDS. 24 (4): 583–92. doi:10.1097/QAD.0b013e3283353c9e. PMC 3072760. PMID 20009918.
• Uhl GR, Liu QR, Drgon T, et al. (2008). "Molecular genetics of successful smoking cessation: convergent genome-wide association study results". Arch. Gen. Psychiatry. 65 (6): 683–93. doi:10.1001/archpsyc.65.6.683. PMC 2430596. PMID 18519826.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gizatullin RZ, Muravenko OV, Al-Amin AN, et al. (2000). "Human NRG3 gene Map position 10q22-q23". Chromosome Res. 8 (6): 560. doi:10.1023/A:1009232025144. PMID 11032326.
• Panchal H, Wansbury O, Parry S, et al. (2007). "Neuregulin3 alters cell fate in the epidermis and mammary gland". BMC Dev. Biol. 7: 105. doi:10.1186/1471-213X-7-105. PMC 2110892. PMID 17880691.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Wang YC, Chen JY, Chen ML, et al. (2008). "Neuregulin 3 genetic variations and susceptibility to schizophrenia in a Chinese population". Biol. Psychiatry. 64 (12): 1093–6. doi:10.1016/j.biopsych.2008.07.012. PMID 18708184.
• Révillion F, Lhotellier V, Hornez L; et al. (2008). "ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis". Ann. Oncol. 19 (1): 73–80. doi:10.1093/annonc/mdm431. PMID 17962208.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Carteron C, Ferrer-Montiel A, Cabedo H (2006). "Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival". J. Cell. Sci. 119 (Pt 5): 898–909. doi:10.1242/jcs.02799. PMID 16478787.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sonuga-Barke EJ, Lasky-Su J, Neale BM, et al. (2008). "Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan". Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8): 1359–68. doi:10.1002/ajmg.b.30860. PMID 18846501.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Volpi S, Heaton C, Mack K, et al. (2009). "Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia". Mol. Psychiatry. 14 (11): 1024–31. doi:10.1038/mp.2008.52. PMID 18521091.