Neuromedin B receptor

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Neuromedin B receptor
Symbols NMBR ; BB1
External IDs OMIM162341 MGI1100525 HomoloGene20560 IUPHAR: 38 ChEMBL: 3636 GeneCards: NMBR Gene
RNA expression pattern
PBB GE NMBR 207333 at tn.png
More reference expression data
Species Human Mouse
Entrez 4829 18101
Ensembl ENSG00000135577 ENSMUSG00000019865
UniProt P28336 O54799
RefSeq (mRNA) NM_002511 NM_008703
RefSeq (protein) NP_002502 NP_032729
Location (UCSC) Chr 6:
142.06 – 142.09 Mb
Chr 10:
14.71 – 14.77 Mb
PubMed search [1] [2]

The neuromedin B receptor (NMBR), now known as BB1 [1] is a G protein-coupled receptor whose endogenous ligand is neuromedin B.[2]

Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.[3]


  1. ^ "Bombesin Receptors: BB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  2. ^ Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118. 
  3. ^ "Entrez Gene: NMBR neuromedin B receptor". 

Further reading[edit]

  • Corjay MH, Dobrzanski DJ, Way JM, et al. (1991). "Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.". J. Biol. Chem. 266 (28): 18771–9. PMID 1655761. 
  • Wu JM, Hoang DO, Feldman RI (1995). "Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs.". Mol. Pharmacol. 47 (4): 871–81. PMID 7723750. 
  • Benya RV, Kusui T, Pradhan TK, et al. (1995). "Expression and characterization of cloned human bombesin receptors.". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118. 
  • Bitar KN, Zhu XX (1994). "Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction.". Gastroenterology 105 (6): 1672–80. PMID 8253343. 
  • Giladi E, Nagalla SR, Spindel ER (1993). "Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides.". J. Mol. Neurosci. 4 (1): 41–54. doi:10.1007/BF02736689. PMID 8391296. 
  • Fathi Z, Benya RV, Shapira H, et al. (1993). "The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding.". J. Biol. Chem. 268 (20): 14622–6. PMID 8392057. 
  • Kane MA, Toi-Scott M, Johnson GL, et al. (1996). "Bombesin-like peptide receptors in human bronchial epithelial cells.". Peptides 17 (1): 111–8. doi:10.1016/0196-9781(95)02088-8. PMID 8822519. 
  • Sainz E, Akeson M, Mantey SA, et al. (1998). "Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor.". J. Biol. Chem. 273 (26): 15927–32. doi:10.1074/jbc.273.26.15927. PMID 9632639. 
  • Lee S, Kim Y (1999). "Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy.". FEBS Lett. 460 (2): 263–9. doi:10.1016/S0014-5793(99)01346-0. PMID 10544247. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Matusiak D, Glover S, Nathaniel R, et al. (2005). "Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon.". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G718–28. doi:10.1152/ajpgi.00156.2004. PMID 15528253. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.