Amino acid transporter

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Transmembrane amino acid transporter protein
Symbol Aa_trans
Pfam PF01490
InterPro IPR013057
TCDB 2.A.18

An amino acid transporter is a membrane transport protein that transports amino acids. They are mainly of the solute carrier family.


There are several families that function in amino acid transport, some of these include:

Solute carrier family examples[edit]


Vesicular inhibitory amino acid transporter (VIAAT) is responsible for the storage of GABA and glycine in neuronal synaptic vesicles.[13]

Human proteins containing this domain[edit]

ATA2; SLC32A1; SLC36A1; SLC36A2; SLC36A3; SLC36A4; SLC38A1; SLC38A2; SLC38A3; SLC38A4; SLC38A5; SLC38A6;

See also[edit]


  1. ^ Kanai Y, Hediger MA (2004). "The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects". Pflugers Arch. 447 (5): 469–479. PMID 14530974. doi:10.1007/s00424-003-1146-4. 
  2. ^ Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflugers Arch. 447 (5): 490–494. PMID 14770309. doi:10.1007/s00424-003-1062-7. 
  3. ^ Singh SK, Piscitelli CL, Yamashita A, Gouaux E (2008). "A competitive inhibitor traps LeuT in an open-to-out conformation". Science. 322 (5908): 1655–1661. PMC 2832577Freely accessible. PMID 19074341. doi:10.1126/science.1166777. 
  4. ^ Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters". Pflugers Arch. 447 (5): 532–542. PMID 14770310. doi:10.1007/s00424-003-1086-z. 
  5. ^ Daniel H, Kottra G (2004). "The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology". Pflugers Arch. 447 (5): 610–618. PMID 12905028. doi:10.1007/s00424-003-1101-4. 
  6. ^ Reimer RJ, Edwards RH (2004). "Organic anion transport is the primary function of the SLC17/type I phosphate transporter family". Pflugers Arch. 447 (5): 629–635. PMID 12811560. doi:10.1007/s00424-003-1087-y. 
  7. ^ Eiden LE, Schafer MK, Weihe E, Schutz B (2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflugers Arch. 447 (5): 636–640. PMID 12827358. doi:10.1007/s00424-003-1100-5. 
  8. ^ Palmieri F (2004). "The mitochondrial transporter family (SLC25): physiological and pathological implications". Pflugers Arch. 447 (5): 689–709. PMID 14598172. doi:10.1007/s00424-003-1099-7. 
  9. ^ Mount DB, Romero MF (2004). "The SLC26 gene family of multifunctional anion exchangers". Pflugers Arch. 447 (5): 710–721. PMID 12759755. doi:10.1007/s00424-003-1090-3. 
  10. ^ Gasnier B (2004). "The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids". Pflugers Arch. 447 (5): 752–755. PMID 12750892. doi:10.1007/s00424-003-1091-2. 
  11. ^ Boll M, Daniel H, Gasnier B (2004). "The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis family". Pflugers Arch. 447 (5): 776–779. PMID 12748860. doi:10.1007/s00424-003-1073-4. 
  12. ^ Mackenzie B, Erickson JD (2004). "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family". Pflugers Arch. 447 (5): 784–795. PMID 12845534. doi:10.1007/s00424-003-1117-9. 
  13. ^ [Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in {alpha}TC6 Cells, Mouse Clonal {alpha}-Cells, and {alpha}-Cells of Islets of Langerhans] Diabetes 52:2066-2074, 2003