Neutrophil cytosolic factor 2

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NCF2
Protein NCF2 PDB 1e96.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNCF2, NCF-2, NOXA2, P67-PHOX, P67PHOX, Neutrophil cytosolic factor 2
External IDsOMIM: 608515 MGI: 97284 HomoloGene: 374 GeneCards: NCF2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000433
NM_001127651
NM_001190789
NM_001190794

NM_010877

RefSeq (protein)

NP_000424
NP_001121123
NP_001177718
NP_001177723

NP_035007

Location (UCSC)Chr 1: 183.56 – 183.59 MbChr 1: 152.68 – 152.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neutrophil cytosol factor 2 is a protein that in humans is encoded by the NCF2 gene.

Function[edit]

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116701 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026480 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NCF2 neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)".

Further reading[edit]

External links[edit]

  • Overview of all the structural information available in the PDB for UniProt: P19878 (Neutrophil cytosol factor 2) at the PDBe-KB.