Neutrophil to lymphocyte ratio
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In medicine neutrophil to lymphocyte ratio (NLR) is used as a marker of subclinical inflammation. It is calculated by dividing the number of neutrophils by number of lymphocytes, usually from peripheral blood sample, but sometimes also from cells that infiltrate tissue, such as tumor. Recently Lymphocyte Monocyte ratio (LMR) has also been studied as a marker of inflammation including Tuberculosis and various cancers.
Prognosis of cardiovascular diseases
Prognostic marker in cancer
Neutrophil to Lymphocyte ratio was first demonstrated as useful parameter after a correlation of a relationship between the neutrophil lymphocyte ratio to reactions of the immune response was noted. A study in 2001 was conducted by the Department of Anaesthesiology and Intensive Care Medicine, St. Elizabeth Cancer Institute in Bratislava by Zahorec which suggested the routine used of the ratio as a stress factor in clinical ICU practice in intervals of 6-12 and 24 hours.
The first study to demonstrate that pretherapuetic NLR can be used as a predictor of chemotherapy sensitivity to thoracic esophageal cancer was demonstrated by Hiroshi Sato, Yasuhiro Tsubosa, and Tatsuyuki Kawano in a 2012 study published in World Journal of Surgery journal.
Notes and references
- Wang X (Mar 2014). "Neutrophil to lymphocyte ratio in relation to risk of all-cause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization : A meta-analysis of observational studies". Atherosclerosis. 234 (1): 206–13. doi:10.1016/j.atherosclerosis.2014.03.003. PMID 24681815.
- Wang J (Jan 2014). "The clinical significance of tumor-infiltrating neutrophils and neutrophil-to-CD8+lymphocyte ratio in patients with resectable esophageal squamous cell carcinoma". J. Transl. Med. 12: 7. doi:10.1186/1479-5876-12-7. PMC 3895663. PMID 24397835.
- Templeton AJ, McNamara MG, Šeruga B, Vera-Badillo FE, Aneja P, Ocaña A, Leibowitz-Amit R, Sonpavde G, Knox JJ, Tran B, Tannock IF, Amir E (2014). "Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis". J. Natl. Cancer Inst. 106 (6): dju124. doi:10.1093/jnci/dju124. PMID 24875653.
- Xue P (Apr 2014). "Neutrophil-to-lymphocyte ratio for predicting palliative chemotherapy outcomes in advanced pancreatic cancer patients". Cancer Med. 3 (2): 406–15. doi:10.1002/cam4.204. PMC 3987090. PMID 24519894.
- Forget, Patrice (2017). "What is the normal value of the neutrophil-to-lymphocyte ratio?". BMC Research Notes. 10 (1): 12. doi:10.1186/s13104-016-2335-5. PMC 5217256. PMID 28057051.
- Zahorec, R. (2001). "Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill". Bratislavske Lekarske Listy. Bratisl Lek Listy. 102 (1): 5–14. PMID 11723675.
- Sato, Hiroshi; Tsubosa, Yasuhiro; Kawano, Tatsuyuki (March 2012). "Correlation Between the Pretherapeutic Neutrophil to Lymphocyte Ratio and the Pathologic Response to Neoadjuvant Chemotherapy in Patients With Advanced Esophageal Cancer". World Journal of Surgery. 36 (3): 617–622. doi:10.1007/s00268-011-1411-1. PMID 22223293.
- Socorro Faria, Sara; Fernandes Jr, Paulo César; Barbosa Silva, Marcelo José; Lima, Vladmir C; Fontes, Wagner; Freitas-Junior, Ruffo; Eterovic, Agda Karina; Forget, Patrice (12 December 2016). "The neutrophil-to-lymphocyte ratio: a narrative review". Ecancermedicalscience. 10: 702. doi:10.3332/ecancer.2016.702. PMC 5221645. PMID 28105073. for risk stratification for breast cancer
- Tang, Xingxing; Du, Peng; Yang, Yong (27 July 2017). "The clinical use of neutrophil-to-lymphocyte ratio in bladder cancer patients: a systematic review and meta-analysis". International Journal of Clinical Oncology. 22 (5): 817–825. doi:10.1007/s10147-017-1171-5. PMID 28752351.
- Huang, Qi-tao; Zhou, Lin; Zeng, Wen-juan; Ma, Qian-qian; Wang, Wei; Zhong, Mei; Yu, Yan-hong (2017). "Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Ovarian Cancer: A Systematic Review and Meta-Analysis of Observational Studies". Cellular Physiology and Biochemistry. 41 (6): 2411–2418. doi:10.1159/000475911. PMID 28467978.
- Yin, Xiaotao; Xiao, Yi; Li, Fanglong; Qi, Siyong; Yin, Zhaoyang; Gao, Jiangping (January 2016). "Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Prostate Cancer". Medicine. 95 (3): e2544. doi:10.1097/MD.0000000000002544. PMC 4998274. PMID 26817900.
- Azab, Basem; Camacho-Rivera, Marlene; Taioli, Emanuela; Zhang, Jian (6 November 2014). "Average Values and Racial Differences of Neutrophil Lymphocyte Ratio among a Nationally Representative Sample of United States Subjects". PLoS ONE. 9 (11): e112361. Bibcode:2014PLoSO...9k2361A. doi:10.1371/journal.pone.0112361. PMC 4223021. PMID 25375150.