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New Madrid may refer to:
- New Madrid County, Missouri, a county in the U.S. state of Missouri
- New Madrid, Missouri, a city in New Madrid County
- New Madrid Seismic Zone, a major seismic zone in Missouri, Tennessee, and Arkansas
- New Madrid earthquake, a series of four earthquakes that occurred in late 1811 and early 1812
- "New Madrid" (song), by Uncle Tupelo from their 1993 album Anodyne
- New Madrid, a literary journal published by Murray State University
| disambiguation page lists articles associated with the title New Madrid.
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