New York Genome Center
|Research type||Basic (non-clinical), Clinical research and translational research|
Field of research
|Genomics, Bioinformatics, DNA sequencing, Whole genome sequencing|
|President||Cheryl A. Moore|
|Location||New York City, New York, United States|
|Website||New York Genome Center|
The New York Genome Center (NYGC) is a 501(c)(3) nonprofit biomedical research organization in New York, New York. A collaboration of academic, medical and industry leaders in New York and other partners throughout the country, the New York Genome Center focuses on translating genomic research into clinical solutions for serious diseases. NYGC faculty hold joint academic appointments at its member institutions and lead clinically focused genomic studies in a number of disease areas, including pediatric and adult cancer, asthma, autism, Alzheimer’s disease, ALS and other serious neurodegenerative diseases. NYGC scientists brings a multidisciplinary and in-depth approach to the field of genomics, conducting research in a wide range of areas, including single cell genomics, gene engineering, population and evolutionary genomics, technology and methods development, statistics, computational biology and bioengineering.
The Center was legally founded in November 2011 as a collaboration among eleven academic institutions to advance genome research, based on leadership from Tom Maniatis and financial support of $2.5 million from each institution as well as a number of private philanthropists, including then Mayor Michael Bloomberg, James Simons and Russell Carson. One year after its founding, NYGC recruited Robert B. Darnell as President and Scientific Director, and formally opened in a newly built facility on September 19–20, 2013.
From November 2012 to December 2016[update], the Center's President and CEO was Robert B. Darnell. During this period, NYGC had a number of major accomplishments, including the hiring of 17 full time and part time NYGC faculty, award of a $40 million grant to Dr. Darnell as Principal Investigator from the National Human Genome Research Institute to create a Center for Common Disease focused on autism, fundraising that included a $55 million grant from New York State to support genomic medicine, a $100 million matching grant from the Simons Foundation and Carson Family Charitable Trust, a $13.5 million contract from NHLBI, a PCORI grant to centralize clinical data in New York, and collaborations with IBM to explore and develop the use of Watson for Genomics in glioblastoma and more generally in cancer genomics. As of 2016[update], though the majority of participating institutions remained New York state-based, two institutions were from outside New York: Jackson lab and Princeton University.
The 12 founding institutions (Albert Einstein College of Medicine joined the original 11 institutions on April 2013) were:
- Cold Spring Harbor Laboratory (New York)
- Columbia University (New York)
- Cornell University / Weill Cornell Medical College (New York)
- Memorial Sloan Kettering Cancer Center (New York)
- Icahn School of Medicine at Mount Sinai (New York)
- New York—Presbyterian Hospital (New York)
- NYU School of Medicine (New York)
- Northwell Health (New York)
- The Jackson Laboratory (Maine)
- Rockefeller University (New York)
- Stony Brook University (New York)
- Albert Einstein College of Medicine (New York)
The Center has 170,000 square feet (16,000 m2) of space in a multi-story building at 101 Avenue of the Americas. By the end of 2015[update], the Center had acquired 16 Illumina HiSeq X Ten and 12 HiSeq 2500 sequencing instruments.
Finances and projects
As of 2016[update], the Center's revenue came from US and New York state governments, a contract with 10 medical institutes for central management of clinical data, and a couple of charitable foundations. This includes funds pledged by the Simons Foundation and the Carson Family Charitable Trust of up to $100 million from 2016 to 2019.
Government funding has included a $40 million grant in 2016 for establishing a Center for Common Disease Genomics from the National Human Genome Research Institute, the aim of which is to describe a comprehensive list of genes underlying common diseases. Also in 2016, the Center and Weill Cornell Medicine received a National Cancer Institute grant to support a joint cancer genomics data center for the research and clinical interpretation of tumors, a part of the ongoing development of The Cancer Genome Atlas; the grant provides $490,000 per year for five years.
National Tumor Registry
In February 2016, the Center started a collaboration with IBM to create a tumor registry matching tumor characteristics and therapeutic responsiveness to genetic profiles among cancer patients. The work has been part of the US Government Precision Medicine Initiative and has employed the Watson system.
Two years prior to this, the Center and IBM collaborated on development of an early version of the tumor registry focused on glioblastoma multiforme, utilizing a pre-production version of Watson Discovery Advisor.
- Robert Darnell, Founding Director
- Harold Varmus, senior associate core member
- Michael Wigler, senior associate core member
- Simon Tavaré, senior scientist
- NYGC is among several recipients, another being the Broad Institute.
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