New York Genome Center

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New York Genome Center
Nygenomelogo-color300px.png
Established 2011 (2011)
Research type Basic (non-clinical), Clinical research and translational research
Field of research
Genomics, Bioinformatics, DNA sequencing, Whole genome sequencing
President Cheryl A. Moore[1]
Location New York City, New York, United States
Affiliations
Website New York Genome Center

The New York Genome Center (NYGC) is a 501(c)(3) nonprofit biomedical research organization in New York, New York.[3] A collaboration of academic, medical and industry leaders in New York and other partners throughout the country, the New York Genome Center focuses on translating genomic research into clinical solutions for serious diseases. NYGC faculty hold joint academic appointments at its member institutions and lead clinically focused genomic studies in a number of disease areas, including pediatric and adult cancer, asthma, autism, Alzheimer’s disease, ALS and other serious neurodegenerative diseases. NYGC scientists brings a multidisciplinary and in-depth approach to the field of genomics, conducting research in a wide range of areas, including single cell genomics, gene engineering, population and evolutionary genomics, technology and methods development, statistics, computational biology and bioengineering.[4]

Founding[edit]

The Center was legally founded in November 2011 as a collaboration among eleven academic institutions to advance genome research,[5] based on leadership from Tom Maniatis[6] and financial support of $2.5 million from each institution as well as a number of private philanthropists, including then Mayor Michael Bloomberg, James Simons and Russell Carson.[5] One year after its founding, NYGC recruited Robert B. Darnell as President and Scientific Director,[7] and formally opened in a newly built facility on September 19–20, 2013.[8][9]

From November 2012 to December 2016, the Center's President and CEO was Robert B. Darnell.[10][7] During this period, NYGC had a number of major accomplishments,[10] including the hiring of 17 full time and part time NYGC faculty,[11] award of a $40 million grant to Dr. Darnell as Principal Investigator from the National Human Genome Research Institute to create a Center for Common Disease focused on autism,[12] fundraising that included a $55 million grant from New York State to support genomic medicine,[13] a $100 million matching grant from the Simons Foundation and Carson Family Charitable Trust,[14][15] a $13.5 million contract from NHLBI, a PCORI grant to centralize clinical data in New York,[10] and collaborations with IBM to explore and develop the use of Watson for Genomics in glioblastoma[16] and more generally in cancer genomics.[17] As of 2016, though the majority of participating institutions remained New York state-based, two institutions were from outside New York: Jackson lab and Princeton University.

The 12 founding institutions (Albert Einstein College of Medicine joined the original 11 institutions on April 2013)[18] were:

Facility[edit]

The Center has 170,000 square feet (16,000 m2) of space in a multi-story building at 101 Avenue of the Americas.[10][19] By the end of 2015, the Center had acquired 16 Illumina HiSeq X Ten and 12 HiSeq 2500 sequencing instruments.[20]

Finances and projects[edit]

As of 2016, the Center's revenue came from US and New York state governments, a contract with 10 medical institutes for central management of clinical data, and a couple of charitable foundations.[10] This includes funds pledged by the Simons Foundation and the Carson Family Charitable Trust of up to $100 million from 2016 to 2019.[14][15]

Government funding has included a $40 million grant in 2016 for establishing a Center for Common Disease Genomics from the National Human Genome Research Institute, the aim of which is to describe a comprehensive list of genes underlying common diseases.[15] Also in 2016, the Center and Weill Cornell Medicine received a National Cancer Institute grant to support a joint cancer genomics data center for the research and clinical interpretation of tumors, a part of the ongoing development of The Cancer Genome Atlas; the grant provides $490,000 per year for five years.[21]

In 2015, the Center won a $13.5 million contract to conduct whole genome sequencing and analysis for the National Heart, Lung, and Blood Institute's TOPMed program.[20][a]

National Tumor Registry[edit]

In February 2016, the Center started a collaboration with IBM to create a tumor registry matching tumor characteristics and therapeutic responsiveness to genetic profiles among cancer patients.[10][22] The work has been part of the US Government Precision Medicine Initiative and has employed the Watson system.[10][22]

Two years prior to this, the Center and IBM collaborated on development of an early version of the tumor registry focused on glioblastoma multiforme,[23] utilizing a pre-production version of Watson Discovery Advisor.[24][25][26]

Notable associates[edit]

Notes[edit]

  1. ^ NYGC is among several recipients, another being the Broad Institute.

Recent Publications[edit]

References[edit]

  1. ^ https://www.genomeweb.com/columns/people-news-cheryl-moore-hilde-windels-and-more[full citation needed]
  2. ^ http://www.nygenome.org/about-us/#our_members[full citation needed]
  3. ^ Duignan, Christopher (13 August 2015). "Form 990: Return of Organization Exempt From Income Tax" (PDF). GuideStar. p. 1. Retrieved 22 November 2016. (Registration required (help)). 
  4. ^ http://www.nygenome.org/wp-content/uploads/2017/04/AAG_Formatted.pdf[full citation needed]
  5. ^ a b "New York Genome Center Launches Unprecedented Collaboration of 11 Leading Medical/Research Institutions". newsroom.cumc.columbia.edu. November 3, 2011. Retrieved 26 March 2017. 
  6. ^ "Tom Maniatis’ Dream of a NY Genome Center Becomes a Big Apple Reality". www.xconomy.com. Retrieved 26 March 2017. 
  7. ^ a b c "Robert Darnell named President of New York Genome Center". Rockefeller University Newswire. November 28, 2012. Retrieved 26 March 2017. 
  8. ^ Maher, Brendan (2013). "Biomedical-research hub opens in Manhattan". Nature. doi:10.1038/nature.2013.13740. 
  9. ^ Matheson, Sarah. "Genome Center Opens in New York". Epoch Times. Retrieved 26 March 2017. 
  10. ^ a b c d e f g h i Rosenthal, Eric T. (9 March 2016). "A New 'Manhattan Project': New York Genome Center". MedPage Today. Retrieved 21 November 2016. 
  11. ^ "Faculty". NYGC: About Us: Faculty. Retrieved 26 March 2017. 
  12. ^ "NIH News Release". NIH genome sequencing program targets the genomic bases of common, rare disease. Retrieved 26 March 2017. 
  13. ^ "Moving the New NY Forward (pdf)" (PDF). Retrieved 27 March 2017. 
  14. ^ a b Di Mento, Maria (25 January 2016). "$100 Million for Genome Center and $75 Million for Hospital". Gifts Roundup. The Chronicle of Philanthropy. New York Genome Center. Retrieved 22 November 2016. 
  15. ^ a b c Lagasse, Jeff (21 January 2016). "New York Genome Center scores $100 million from James Simons, Russell Carson". Healthcare Finance. Retrieved 22 November 2016. 
  16. ^ "IBM’s Watson, New York Genome Center partner on brain cancer treatment". Washington Post. Retrieved 26 March 2017. 
  17. ^ Cha, Ariana. "IBM and New York Genome Center’s new cancer tumor repository aims to revolutionize treatment". www.washingtonpost.com. Retrieved 26 March 2017. 
  18. ^ "Einstein joins NYGC as 12th Founding Member". Retrieved 26 March 2017. 
  19. ^ Hargittai, István; Hargittai, Magdolna (2016). New York Scientific: A Culture of Inquiry, Knowledge, and Learning. Oxford, United Kingdom: Oxford University Press. p. 167. ISBN 9780191084683 – via Google Books. 
  20. ^ a b "NY Genome Center Wins $13.5M from NHLBI Precision Medicine Program". GenomeWeb. 29 October 2015. Retrieved 22 November 2016. (Registration required (help)). 
  21. ^ "Weill Cornell Medicine and the New York Genome Center Awarded NCI Grant to Create Genomic Data Center". Bio-IT World. 3 November 2016. Retrieved 22 November 2016. 
  22. ^ a b Cha, Ariana Eunjung (25 February 2016). "IBM and New York Genome Center’s new cancer tumor repository aims to revolutionize treatment". The Washington Post. Retrieved 21 November 2016. 
  23. ^ Herper, Matthew (19 March 2014). "IBM's Watson Attempts To Tackle The Genetics Of Brain Cancer". Forbes. Retrieved 22 November 2016. 
  24. ^ Jain, Kewal K. (2015). Textbook of Personalized Medicine (2nd ed.). Humana Press. ISBN 978-1-4939-2553-7. OCLC 900623470. doi:10.1007/978-1-4939-2553-7 – via Google Books. [page needed]
  25. ^ Ravindranath, Mohana (29 August 2014). "New Watson incarnation crunches academic literature". The Washington Post. Retrieved 22 November 2016. 
  26. ^ Wang, Baoying (2014). Big Data Analytics in Bioinformatics and Healthcare. Hershey, Pennsylvania: IGI Global. p. 423. ISBN 9781466666122. OCLC 890377536 – via Google Books. 
  27. ^ Reardon, Sara (2015). "Harold Varmus to resign as head of US cancer institute". Nature. doi:10.1038/nature.2015.17063. 
  28. ^ Sunkin-Strube, Alyssa (5 March 2015). "Nobel laureate Harold Varmus to join Weill Cornell April 1". Cornell Chronicle. Retrieved 22 November 2016. 
  29. ^ a b "About Us". New York Genome. Retrieved 2016-12-21.