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Structural formula
Ball-and-stick model
Clinical data
Routes of
Oral, intravenous
ATC code
  • none
Legal status
Legal status
Synonyms 6-Nicotinoyldihydrocodeine
CAS Number
PubChem CID
ECHA InfoCard 100.011.241
Chemical and physical data
Formula C24H26N2O4
Molar mass 406.474 g/mol
3D model (JSmol)

Nicodicodeine is an opioid developed as a cough suppressant and analgesic. Synthesized in 1904, it is not commonly used, but has activity similar to other opioids. Nicodicodeine is metabolised in the liver by demethylation to produce 6-nicotinoyldihydromorphine, and subsequently further metabolised to dihydromorphine. Since the final active metabolite is the slightly stronger opiate dihydromorphine rather than morphine, nicodicodeine can be expected to be marginally more potent and longer acting than nicocodeine. Side effects are similar to those of other opioids and include itching, nausea and respiratory depression.