From Wikipedia, the free encyclopedia
Structural formula
Ball-and-stick model
Clinical data
Other namesNicodicodeine, 6-Nicotinoyldihydrocodeine, Nicodicodina,[1] Nicodicodinum[1]
Routes of
Oral, intravenous
ATC code
  • none
Legal status
Legal status
  • (5alpha,6alpha)-3-Methoxy-17-methyl-4,5-epoxymorphinan-6-yl pyridine-3-carboxylate[7]
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.011.241 Edit this at Wikidata
Chemical and physical data
Molar mass406.482 g·mol−1
3D model (JSmol)
  • CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(CC4)OC(=O)C6=CN=CC=C6
  • InChI=InChI=1S/C24H26N2O4/c1-26-11-9-24-16-6-8-19(29-23(27)15-4-3-10-25-13-15)22(24)30-21-18(28-2)7-5-14(20(21)24)12-17(16)26/h3-5,7,10,13,16-17,19,22H,6,8-9,11-12H2,1-2H3/t16-,17+,19-,22-,24-/m0/s1
 ☒NcheckY (what is this?)  (verify)

Nicodicodine is an opioid developed as a cough suppressant and analgesic.[8] Synthesized in 1904, it is not commonly used, but has activity similar to other opioids.[8] Nicodicodine is metabolised in the liver by demethylation to produce 6-nicotinoyldihydromorphine, and subsequently further metabolised to dihydromorphine. Since the final active metabolite is the slightly stronger opiate dihydromorphine rather than morphine, nicodicodine can be expected to be marginally more potent and longer acting than nicocodeine. Side effects are similar to those of other opioids and include itching, nausea and respiratory depression.


  1. ^ a b "Nicodicodine [INN:BAN:DCF] | SIELC". 16 May 2018. Retrieved 12 January 2019.
  2. ^ "Drugs Misuse Regulation 1987". Office of the Queensland Parliamentary Counsel. Retrieved 10 January 2019.
  3. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-03.
  4. ^ "Misuse of Drugs Act 1971". Retrieved 10 January 2019.
  5. ^ "The International Drug Control Conventions". United Nations. Retrieved 10 January 2019.
  6. ^ "Anlage II BtMG - Einzelnorm".
  7. ^ "Chemistry Dashboard". U.S. Environmental Protection Agency. Retrieved 10 January 2019.
  8. ^ a b Stolberg VB (2016). Painkillers: History, Science, and Issues. ABC-CLIO. p. 110. ISBN 978-1-4408-3532-2. Retrieved 12 January 2019.