|Product type||Nicotine replacement therapy product|
|Owner||GlaxoSmithKline (US), Johnson & Johnson (outside the US)|
|Previous owners||AB Leo, Pharmacia, Pfizer|
Nicorette is the brand name of a number of products for nicotine replacement therapy (NRT) that contain nicotine. Developed in late 70s in Sweden by AB Leo in the form of a chewing gum Nicorette was the first nicotine replacement product on the market.
Nicorette product range consists of chewing gum, lozenges, patches of two kinds (transparent and non-transparent), oral spray (Nicorette QuickMist), inhalator, sublingual tablets (Nicorette Microtab) and nasal spray.
Nicorette products are manufactured by McNeil Consumer Healthcare company, a subsidiary of Johnson & Johnson. GlaxoSmithKline is the licence holder of Nicorette Gum in the United States while Johnson & Johnson markets Nicorette globally.
- 1 History
- 2 Mechanism of action
- 3 Therapeutic indications
- 4 Contraindications
- 5 Mechanism of action, formats, dosages and administration
- 6 Brand communication
- 7 See also
- 8 References
- 9 External links
Nicotine gum development
Nicorette brand started from a nicotine chewing gum developed in Helsingborg (Sweden) by Leo AB company (later – part of Pharmacia & Upjohn). It was the first product for nicotine replacement therapy  and gained its inventor Ove Fernö titles like “the founding father of modern pharmacotherapy for smoking”.
1967 – On December 12, 1967:1216 Ove Fernö, Vice President of Research and Development at AB Leo:1215 received a mail from his friend Dr. Claes Lundgren at the Department of Aviation Medicine at the Physiological Institute of Lund University, suggesting to develop an orally consumed substitute for tobacco. He and his colleague Stefan Lichtneckert noted how submariners and aviation crews switched from cigarettes to chewing tobacco and snus when smoking was not possible. They also suggested a product name “Nicorette” (from “nicotine” and Swedish: rette, “right way”).:145
1971 – First nicotine chewing gum produced at AB Leo. The innovation was in the use of ion-exchange resin (polacrilex) in the gum, in order to control the rate of release of nicotine during chewing. As explained by the inventor himself, “Putting nicotine into chewing gum is not an invention. Fixing the nicotine to an ion exchange resin and putting that in a chewing gum to enable the chewer to control the rate of release—that is an invention”.:1220 Same year Håkan Westling, Professor of Clinical Physiology at Lund University, started first clinical trials at the University Hospital in Lund. Results of his findings were presented at the Second World Conference on Smoking and Health in London.:146
1975 – Nicotine chewing gum presented at the Third World Conference on Smoking and Health in New York where Ove Fernö partnered with the British researcher Michael Russell from the Institute of Psychiatry, who pioneered the measurement of blood nicotine levels. Russell and his colleagues at the Addiction Research Unit at the Institute of Psychiatry became involved in further research of nicotine gum through randomized controlled trials funded by the British Medical Research Council and the UK Department of Health and Social Security.:147
1980 – Nicorette registered as a drug in the UK.:147
1981 – Nicorette registered in Sweden. Initially the Swedish Medical Products Agency did not approve Nicorette as a medicine because at that time smoking was considered not an addiction, but a lifestyle choice. Also Swedish National Board of Health and Welfare regarded orally consumed nicotine products not as medicine but as foodstuffs.
1984 – On January 13, 1984 Nicorette chewing gum was approved by the US Food and Drug Administration after a 34-month review. It was brought to the US market by Marion Merrell Dow under the license from AB Leo.
Further product development
1994 - Nasal spray developed.
1996 - Nicorette inhaler launched.
2002 – FDA changed the status of Commit lozenges to the OTC status.
2004 – Nicorette launched Peppermint, the first coated gum. Candy-like shell coating enhanced with a sugar substitute (xylitol) and flavoring allowed to prolong release of flavor and sweeter from chewing gum. This allowed to develop sweeter and better tasting nicotine gums with nice tasting fruity and mint tastes that overpower rather unpleasant taste of nicotine.
2005 – Nicorette introduced Fresh Mint chewing gum.
As stated by Medicines and Healthcare Products Regulatory Agency new patches have been developed from previously available Nicorette Transdermal Patches to:
- reduce the area size of the patch,
- add higher strength of 25 mg nicotine (previous dosage strengths - 5, 10 and 15 mg),
- improve nicotine utilization (increased proportion of bioavailable nicotine),
- introduce a translucent backing layer for a more discreet patch and better consumer compliance.
2010 - In the end of November 2010 Nicorette introduced QuickMist 1 mg mouthspray. This new format of nicotine replacement therapy provided more rapid absorption of nicotine compared with lozenge or gum.
Mechanism of action
The nicotine from Nicorette replaces some of the nicotine the smoker previously got from tobacco smoke; this relieves some of the craving and withdrawal symptoms, and allows the ex-smoker to concentrate on overcoming the habitual action of smoking. Nicotine is the addictive component in cigarette smoke and the reason for smoking, but the harm caused by smoking is mostly due to other components in the smoke such as tar, carbon monoxide and other gases.
The full dose of Nicorette should be used for about eight weeks, and then the dose can gradually be reduced before treatment stops. Nicorette Gum is available in two strengths, either nicotine 2 mg or 4 mg. The nicotine is bound to an ion-exchange resin (polacrilex) in the gum, in order to control the rate of release of nicotine during chewing.
Nicorette products are indicated for the relief of withdrawal symptoms associated with Nicotine withdrawal and to aid in smoking cessation. It is suggested that Nicorette products should be used in "conjunction with a behavioural support programme".
Prior to 2005 nicotine products in Britain were only licensed to "assist smokers who were making an immediate and complete quit attempt" Following advice from a working group set up by the Committee on Safety of Medicines (currently Commission on Human Medicines) MHRA concluded that NRT products should be used also by those why are unable to stop abruptly.
Currently Nicorette products in the UK are indicated to:
- relieve craving (the urge to smoke),
- relieve withdrawal symptoms (irritability, impatience; difficulty in concentrating),
- improve the likelihood of a successful abrupt quit attempt,
- reduce the amount smoked in those not immediately motivated to quit.
The products are intended for adults and children over 12 years of age as well as pregnant and lactating women (it has been concluded that "the use of NRT in pregnancy does not give undue concern and any harm caused by nicotine replacement must be compared with that caused by continued smoking – which is extremely harmful to both the woman and her child").
Nicorette products (like all other NRT products) are most beneficial for heavy smokers (more than 15 cigarettes per day). There are not enough studies to show that NRT helps those who smoke fewer than 10 cigarettes per day.
Up until recently cardiovascular disease was considered to be contraindication to nicotine replacement therapy products. However, in 2003 French French Agency for the Safety of Health Products (AFSSAPS) removed all cardiovascular and cerebrovascular disease contraindications. In 2005 similar action has been taken by the UK’s Medicines and Healthcare Products Regulatory Agency. The rationale behind it is that the benefit of nicotine replacement therapy outweighs the risks of nicotine medication, even in smokers with cardiovascular disease.
FDA approved labeling for Nicorette products contain warning concerning pregnancy and breastfeeding, stating, "This medicine is believed to be safer than smoking. However, the risks to your child from this medicine are not fully known".
FDA suggests not to use Nicorette products if the patient continues to smoke, chew tobacco, snuff or other nicotine containing products.
Consulting a doctor is advised by FDA before using the product if the patient previously had:
- heart disease, recent heart attack, or irregular heartbeat,
- high blood pressure,
- taken a prescription medicine for depression or asthma.
Specific contraindications from FDA for various formats include sodium-restricted diet, stomach ulcer of diabetes (for gums and lozenges), an allergy to adhesive tape of skin problems (for patch).
It is suggested to stop using Nicorette products in cases of irregular heartbeat or palpitations, symptoms of nicotine overdose (nausea, vomiting, dizziness, weakness, and rapid heartbeat) or skin redness caused by the patch.
Mechanism of action, formats, dosages and administration
Nicorette chewing gum releases nicotine while chewing. Nicotine then is absorbed across the oral mucosa into the systemic circulation. Patients are advised to chew the gum slowly and intermittently to avoid the risk of releasing too much nicotine. It is also suggested not to eat or drink while chewing since foods and beverages can reduce nicotine absorption.
Nicorette chewing gum is available in two strengths: 2 mg/piece and 4 mg/piece. Dosing would depend on the degree of nicotine dependence: light smokers should use 2 mg gum, heavy smokers (more than 25 cigarettes a day) should use 4 mg gum. Patients should chew gum once they feel the craving. The average adult dosage is 9 to 12 pieces per day. FDA limits maximum daily amount of 2 mg gums to 24 pieces.
It is suggested to use gum following a 12-week schedule, reducing the amount of gums consumed by the end of the therapy.
The patches provide slow absorption of nicotine into blood within the day and work for 16 hours. They are usually applied in the morning and removed at bedtime.
The patch supports smoking cessation within 12 week programme: 25 mg patch (25 mg nicotine over 16 hours) for eight weeks (Step 1), 15 mg patch for two weeks (Step 2), 10 mg patch for the last two weeks (Step 3). Light smokers (less than 10 cigarettes per day) were recommended to start at Step 2 (15 mg) for eight weeks and reduce the dose to 10 mg for the last four weeks.
Microtab supplies nicotine to the body orally. It is different from the chewing gum because instead of chewing the patient should allow the tablet to dissolve slowly under the tongue (the tablet dissolves in about 20-30 minutes). The action is similar to 2 mg nicotine gum.
Microtabs are used either for smoking cessation or smoking reduction. For smoking cessation the standard dose is one tablet (2 mg) per hour for patients who smoke less than 20 cigarettes per day. When the craving is strong two tablets can be taken instead of one. Most patients require between 8 to 24 tablets per day. British Medicines and Healthcare Products Regulatory Agency recommends not to exceed 40 tablets per day limit. Treatment should be stopped when daily consumption is around 1-2 tablets per day.
Nicorette QuickMist spray is a liquid solution spray in a polyethylene terephthalate (PET) bottle placed in a dispenser with a mechanical spray pump. One bottle contains 13.2 ml of solution (at least 150 sprays). The solution consists of 1 mg of nicotine, propylene glycol, anhydrous enthanol, trometamol, poloxamer 407, glycerol, sodium hydrogen carbonate, levomenthol, mint flavour, cooling flavour, sucralose, acesulfame potassium, hydrochloric acid and purified water.
Spray is administered when one has a desire to smoke. MHRA suggests not to use more than 2 sprays at a time, up to 4 sprays per hour and no more than 64 sprays per 24 hours period.
Nicorette Quickmist is considered to be the most advanced format of nicotine replacement therapy due to the speed of action. As explained by Gay Sutherland, research Psychologist at the Tobacco Research Unit, Kings College "after taking a puff on a cigarette, smokers get nicotine hit to the brain within around 20 seconds. Most nicotine replacement therapies can take between 30 minutes and three hours to deliver their effect" while Nicorette Quickmist has a proven ability to deliver nicotine to the brain within 60 seconds. There is also clinical data proving that using Nicorette Quickmist double the chances of successfully quitting compared to willpower alone (a relatevie success rate of 2.48 compared to placebo regarding abstinence at 1 year).
Yacht race sponsorship
|“||The tobacco companies were ousted from land-based sports due to legislation that stopped them from promoting themselves in other sports… They all realized that yachting is in international waters, under a totally different legal framework, and they all started to sponsor yachts… I was absolutely furious when yachts (with names of tobacco companies) started arriving on the scene… I thought it was unfair that they were using my sport. It's a green sport, it's a healthy sport ... it is not a sport to be hijacked.||”|
— Ludde Ingvall, in an article
In 1995 Nicorette team was banned from Cape to Rio Race, sponsored by the tobacco company Rothmans. The captain of “Nicorette” protested against the decision by saying that “Rothmans is scared of the boat and the healthy lifestyle it seeks to promote”. Later a spokesperson for the organizing committee of the race admitted that the yacht was barred because they considered the product to be in competition with the sponsor's product. In the same year the yacht won Fastnet Race.
Car race sponsorship
The brand also runs the Nicorette's Quit Crew program to help racers quit smoking.
Apparently the brand is supporting car races because NASCAR fans are heavy smokers.
- Karl Fagerstöm, Anders Axelsson, Lennart Sorelius. "In memoriam of Ove Fernö - the inventor or NRT and The Past, Present, and Future of NRT". Society for Research on Nicotine and Tobacco Newsletter, September/October 2008, vol. 14, № 3. Archived from the original (PDF) on 2014-12-25. Retrieved 2014-12-25.
During the late 1960s and 70s he was responsible for the development of the first NR product – a chewing gum
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