Nicotinamide mononucleotide

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Nicotinamide mononucleotide
Nicotinamide mononucleotide.svg
IUPAC name
Other names
  • Nicotinamide ribonucleoside 5'-phosphate
  • Nicotinamide D-ribonucleotide
  • β-Nicotinamide ribose monophosphate
  • Nicotinamide nucleotide
3D model (JSmol)
ECHA InfoCard 100.012.851 Edit this at Wikidata
Molar mass 334.221 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Nicotinamide mononucleotide ("NMN", "NAMN", and "β-NMN") is a nucleotide derived from ribose and nicotinamide.[1] NMN is made from B vitamins in the body, and is a molecule naturally occurring in all life forms.[2] Like nicotinamide riboside, NMN is a derivative of niacin,[3] and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide (NADH).[1] In mice, NMN enters cells via the small intestines within 10 minutes converting to NAD+ through the Slc12a8 NMN transporter.[4]

Because NADH is a cofactor for processes inside mitochondria, for sirtuins, and for PARP, NMN has been studied in animal models as a potential neuroprotective and anti-aging agent.[5][6] Dietary supplement companies have aggressively marketed NMN products claiming those benefits.[7] Doses of up to 500 mg was shown safe in men in a recent human study[8] at Keio University School of Medicine, Shinjuku, Tokyo Japan. Multiple long-term human studies are underway.[9][10]

Nicotinamide riboside (NR) kinase enzymes are essential for exogenously administered utilization of NR and NMN.[11][12] When administered exogenously, NMN must be converted to NR in order to enter a cell and be re-phosphorylated back to NMN.[11] Both NR and NMN are vulnerable to extracellular degradation by CD38 enzyme.[12]


  1. ^ a b Bogan, KL; Brenner, C (2008). "Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition". Annual Review of Nutrition. 28: 115–30. doi:10.1146/annurev.nutr.28.061807.155443. PMID 18429699.
  2. ^ "What is NMN ?".
  3. ^ "About NMN (Beta-Nicotinamide Mononucleotide)".
  4. ^ "Slc12a8 is a nicotinamide mononucleotide transporter". Nature. January 2019.
  5. ^ Brazill, JM; Li, C; Zhu, Y; Zhai, RG (June 2017). "NMNAT: It's an NAD+ synthase… It's a chaperone… It's a neuroprotector". Current Opinion in Genetics & Development. 44: 156–162. doi:10.1016/j.gde.2017.03.014. PMC 5515290. PMID 28445802.
  6. ^ "Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice". Cell Metabolism. 13 December 2016.
  7. ^ Stipp, David (March 11, 2015). "Beyond Resveratrol: The Anti-Aging NAD Fad". Scientific American Blog Network.
  8. ^ "Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men". Endocrine Journal. November 2019.
  9. ^ "Effect of long-term oral administration of nicotinamide mononucleotide (NMN) on human health".
  10. ^ "Assessment of the safety of long-term nicotinamide mononucleotide (NMN)".
  11. ^ a b Fletcher RS, Lavery GG (2018). "The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism". Journal of Molecular Endocrinology. 61 (1): R107–R121. doi:10.1530/JME-18-0085. PMC 6145238. PMID 30307159.
  12. ^ a b Cambronne XA, Kraus WL (2020). "Location, Location, Location: Compartmentalization of NAD + Synthesis and Functions in Mammalian Cells". Trends in Biochemical Sciences. 45 (10): 858–873. doi:10.1016/j.tibs.2020.05.010. PMC 7502477. PMID 32595066.