Nicotinate-nucleotide diphosphorylase (carboxylating)
|nicotinate-nucleotide diphosphorylase (carboxylating)|
Nicotinate-nucleotide pyrophosphorylase (carboxylating) hexamer, Human
|PDB structures||RCSB PDB PDBe PDBsum|
|Gene Ontology||AmiGO / QuickGO|
- nicotinate D-ribonucleotide + diphosphate + CO2 pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating). Other names in common use include quinolinate phosphoribosyltransferase (decarboxylating), quinolinic acid phosphoribosyltransferase, QAPRTase, NAD+ pyrophosphorylase, nicotinate mononucleotide pyrophosphorylase (carboxylating), and quinolinic phosphoribosyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.
- GHOLSON RK, UEDA I, OGASAWARA N, HENDERSON LM (1964). "THE ENZYMATIC CONVERSION OF QUINOLINATE TO NICOTINIC ACID MONONUCLEOTIDE IN MAMMALIAN LIVER". J. Biol. Chem. 239: 1208–14. PMID 14165928.
- Packman PM, Jakoby WB (1965). "Crystalline quinolinate phosphoribosyltransferase". J. Biol. Chem. 240 (10): 4107–8. PMID 5320648.
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