Nicotinyl alcohol

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Nicotinyl alcohol
Nicotinyl alcohol.png
Systematic (IUPAC) name
(Pyridin-3-yl)methanol
Clinical data
AHFS/Drugs.com Monograph
Identifiers
CAS Number 100-55-0 YesY
ATC code C10AD05 (WHO) C04AC02 (WHO)
PubChem CID 7510
ChemSpider 7229 N
UNII 9TF312056Y N
Chemical data
Formula C6H7NO
Molar mass 109.126 g/mol
 NYesY (what is this?)  (verify)

Nicotinyl alcohol (pyridylcarbinol) is a niacin derivative used as a hypolipidemic agent and as a vasodilator. It causes flushing and may decrease blood pressure.[1]

It appears as a crystal that dissolves in water and alcohol with ease, also soluble in eter; melting range 147-148º.[citation needed]

Nicotinic acid is a brief peripheral vasodilator; this compound was made to make its action longer and effective. It provokes cutaneous flushing in head and upper torax with heat, but with no major effects in blood pressure. It is used in peripheral vascular diseases, like arteriosclerosis obliterans,[2] Raynaud's disease,[3] thromboangiitis obliterans (Buerger's disease),[4] arterial embolism, chilblains or migraine associated with vascular spasm.

Fischer and Tebrock worked with this drug in more than two hundred patients for more than three years, achieving effective improvements, mainly in syntoms related to intermittent claudication,[5] ulcer healing and others.[6]

References[edit]

  1. ^ "Ronicol Retard". Medical Dictionary Online. 2012. Retrieved July 27, 2012. 
  2. ^ Richter IH, Fogel M, Fabricant H (1951). "An evaluation of roniacol tartrate in arteriosclerosis obliterans". New York State Journal of Medicine. 51 (10): 1303–4. PMID 14843421. 
  3. ^ http://www.theodora.com/medical_dictionary/nicotine_nitrocellulose.html
  4. ^ http://es.slideshare.net/ravinarwal/buergers-disease-by-dr-ravinder-narwal Page 18
  5. ^ Gillhespy, RO (1957). "Nicotinyl Alcohol Tartrate in Intermittent Claudication". British Medical Journal. 18 (2): 207–208. PMID 1974214. 
  6. ^ Fisher MM, Tebrock HW (1953). "Nicotinic alcohol (roniacol) in peripheral vascular diseases and allied conditions: its use and limitations". New York State Journal of Medicine. 53 (1): 65–8. PMID 13025721.