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Nidogens, formerly known as entactins, are a family of sulfated monomeric glycoproteins located in the basal lamina.[1] Two nidogens have been identified in humans: nidogen-1 (NID1) and nidogen-2 (NID2).[2] Nidogens have been shown to play a crucial role during organogenesis in late embryonic development, particularly in cardiac and lung development.[3]


  1. ^ Hortsch, Michael; Umemori, Hisashi (2009). The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance. New York, NY: Springer. p. 66.
  2. ^ Miosge, N; Holzhausen, S; Zelent, C; Sprysch, P; Herken, R (2001). "Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development". The Histochemical Journal. 33 (9–10): 523–30. doi:10.1023/A:1014995523521. PMID 12005023.
  3. ^ Bader, B. L.; Smyth, N.; Nedbal, S.; Miosge, N.; Baranowsky, A.; Mokkapati, S.; Murshed, M.; Nischt, R. (15 July 2005). "Compound Genetic Ablation of Nidogen 1 and 2 Causes Basement Membrane Defects and Perinatal Lethality in Mice". Molecular and Cellular Biology. 25 (15): 6846–6856. doi:10.1128/MCB.25.15.6846-6856.2005. PMC 1190363. PMID 16024816.