Nipecotic acid

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Nipecotic acid
Nipecotic acid.png
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
ECHA InfoCard 100.007.159 Edit this at Wikidata
Chemical and physical data
Formula C6H11NO2
Molar mass 129.16 g/mol
3D model (JSmol)

Nipecotic acid is a GABA uptake inhibitor[1] used in scientific research.[2][3]

See also[edit]

References[edit]

  1. ^ Macdonald, R.L. (2012). Eadie, Mervyn J.; Vajda, Frank J. E., eds. Antiepileptic drugs: pharmacology and therapeutics (First ed.). [S.l.]: Springer. p. 130. ISBN 978-3-642-64244-9. In contrast, prolonged (1 h) exposure to gabapentin enhanced the shunting effect on CAl region excitatory postsynaptic potentials induced by the GABA uptake inhibitor, nipecotic acid, which promotes GABA release. 
  2. ^ Takahashi K, Miyoshi S, Kaneko A, Copenhagen DR (1995). "Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina". Jpn. J. Physiol. 45 (3): 457–73. doi:10.2170/jjphysiol.45.457. PMID 7474528. 
  3. ^ Wahab A, Heinemann U, Albus K (October 2009). "Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures". Epilepsy Research. 86 (2-3): 113–23. doi:10.1016/j.eplepsyres.2009.05.008. PMID 19535226.