Niperotidine

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Niperotidine
Niperotidine.svg
Names
IUPAC name
(Z)-1-N′-(1,3-Benzodioxol-5-ylmethyl)-1-N-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-2-nitroethene-1,1-diamine
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.076.612
EC Number 284-304-0
KEGG
MeSH C073716
UNII
Properties
C20H26N4O5S
Molar mass 434.51 g·mol−1
Pharmacology
A02BA05 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Niperotidine is a histamine antagonist selective for the H2 subtype. It was studied as a treatment for excessive gastric acidity,[1] but withdrawn after human trials showed liver damage.[2]

References[edit]

  1. ^ Palasciano, G; Maggi, V; Portincasa, P (1990). "The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring". The Italian journal of gastroenterology. 22 (5): 291–4. PMID 1983712. 
  2. ^ Gasbarrini, G; Gentiloni, N; Febbraro, S; Gasbarrini, A; Di Campli, C; Cesana, M; Miglio, F; Miglioli, M; Ghinelli, F; d'Ambrosi, A; Amoroso, P; Pacini, F; Salvadori, G (1997). "Acute liver injury related to the use of niperotidine". Journal of hepatology. 27 (3): 583–6. PMID 9314138.