Niperotidine

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Niperotidine
Niperotidine.svg
Names
IUPAC name
(Z)-1-N'-(1,3-benzodioxol-5-ylmethyl)-1-N-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-2-nitroethene-1,1-diamine
Identifiers
3D model (Jmol)
ChemSpider
ECHA InfoCard 100.076.612
EC Number 284-304-0
KEGG
MeSH C073716
UNII
Properties
C20H26N4O5S
Molar mass 434.50924 g/mol
Pharmacology
A02BA05 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Niperotidine is a histamine antagonist selective for the H2 subtype. It was trialled as a treatment for excessive gastric acidity,[1] but withdrawn after human trials showed liver damage.[2]

References[edit]

  1. ^ Palasciano G, Maggi V, Portincasa P. The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. Italian Journal of Gastroenterology. 1990 Oct;22(5):291-4. PMID 1983712
  2. ^ Gasbarrini G, Gentiloni N, Febbraro S, Gasbarrini A, Di Campli C, Cesana M, Miglio F, Miglioli M, Ghinelli F, D'Ambrosi A, Amoroso P, Pacini F, Salvadori G. Acute liver injury related to the use of niperotidine. Journal of Hepatology. 1997 Sep;27(3):583-6. PMID 9314138