Nitric oxide synthase 2 (inducible)

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NOS2
PDB 1nsi EBI.jpg
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNOS2, HEP-NOS, INOS, NOS, NOS2A, Nitric oxide synthase 2
External IDsMGI: 97361 HomoloGene: 55473 GeneCards: NOS2
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for NOS2
Genomic location for NOS2
Band17q11.2Start27,756,766 bp[1]
End27,800,499 bp[1]
RNA expression pattern
PBB GE NOS2A 210037 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000625
NM_153292

NM_010927
NM_001313921
NM_001313922

RefSeq (protein)

NP_000616

NP_001300850
NP_001300851
NP_035057

Location (UCSC)Chr 17: 27.76 – 27.8 MbChr 11: 78.92 – 78.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.[5]

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in the liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[6]

Interactions[edit]

Nitric oxide synthase 2A has been shown to interact with Caveolin 1[7] and Rac2.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007171 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020826 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR (May 1993). "Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes". Proc Natl Acad Sci USA. 90 (8): 3491–5. doi:10.1073/pnas.90.8.3491. PMC 46326Freely accessible. PMID 7682706. 
  6. ^ "Entrez Gene: NOS2A nitric oxide synthase 2A (inducible, hepatocytes)". 
  7. ^ Felley-Bosco E, Bender FC, Courjault-Gautier F, Bron C, Quest AF (December 2000). "Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14334–9. doi:10.1073/pnas.250406797. PMC 18919Freely accessible. PMID 11114180. 
  8. ^ Kuncewicz T, Balakrishnan P, Snuggs MB, Kone BC (August 2001). "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages". Am. J. Physiol. Renal Physiol. 281 (2): F326–36. PMID 11457725.