Nitric oxide synthase 2 (inducible)

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Nitric oxide synthase 2, inducible
PDB 1nsi EBI.jpg
Rendering of 1NSI
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM163730 MGI97361 HomoloGene55473 ChEMBL: 4481 GeneCards: NOS2 Gene
EC number
RNA expression pattern
PBB GE NOS2A 210037 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4843 18126
Ensembl ENSG00000007171 ENSMUSG00000020826
UniProt P35228 P29477
RefSeq (mRNA) NM_000625 NM_010927
RefSeq (protein) NP_000616 NP_035057
Location (UCSC) Chr 17:
27.76 – 27.8 Mb
Chr 11:
78.92 – 78.96 Mb
PubMed search [1] [2]

Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.[1]

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[2]


Nitric oxide synthase 2A has been shown to interact with Caveolin 1[3] and Rac2.[4]


  1. ^ Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR (May 1993). "Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes". Proc Natl Acad Sci USA 90 (8): 3491–5. doi:10.1073/pnas.90.8.3491. PMC 46326. PMID 7682706. 
  2. ^ "Entrez Gene: NOS2A nitric oxide synthase 2A (inducible, hepatocytes)". 
  3. ^ Felley-Bosco E, Bender FC, Courjault-Gautier F, Bron C, Quest AF (December 2000). "Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14334–9. doi:10.1073/pnas.250406797. PMC 18919. PMID 11114180. 
  4. ^ Kuncewicz T, Balakrishnan P, Snuggs MB, Kone BC (August 2001). "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages". Am. J. Physiol. Renal Physiol. 281 (2): F326–36. PMID 11457725.