Inert gas asphyxiation
Inert gas asphyxiation is a form of asphyxiation which results from breathing a physiologically inert gas in the absence of oxygen, or a low amount of oxygen, rather than atmospheric air (which is largely composed of nitrogen and oxygen). Examples of physiologically inert gases, which have caused accidental or deliberate death by this mechanism, are argon, helium, nitrogen, and methane. The term "physiologically inert" is used to indicate a gas which has no toxic or anesthetic properties and does not act upon the heart or hemoglobin. Instead, the gas acts as a simple diluent to reduce oxygen concentration in inspired gas and blood to dangerously low levels, thereby eventually depriving all cells in the body of oxygen.
According to the U.S. Chemical Safety and Hazard Investigation Board, in humans, "breathing an oxygen deficient atmosphere can have serious and immediate effects, including unconsciousness after only one or two breaths. The exposed person has no warning and cannot sense that the oxygen level is too low." In the US, at least 80 people died due to accidental nitrogen asphyxiation between 1992 and 2002. Hazards with inert gases and the risks of asphyxiation are well established.
An occasional cause of accidental death in humans, inert gas asphyxia with gases including helium, nitrogen, methane, and argon, has been used as a suicide method. Inert gas asphyxia has been advocated by proponents of euthanasia, using a gas-retaining plastic hood device colloquially referred to as a suicide bag.
Nitrogen asphyxiation has been suggested by a number of lawmakers and other advocates as an allegedly more humane way to carry out capital punishment. In April 2015, the Oklahoma Governor Mary Fallin signed a bill authorizing nitrogen asphyxiation as an alternative execution method in cases where the state's preferred method of lethal injection was not available as an option.
When humans breathe in an asphyxiant gas, such as pure nitrogen, helium, neon, argon, sulfur hexafluoride, methane, or any other physiologically inert gas(es), they exhale carbon dioxide without re-supplying oxygen. Physiologically inert gases (those that have no toxic effect, but merely dilute oxygen) are generally free of odor and taste. As such, the human subject detects little abnormal sensation as the oxygen level falls. This leads to asphyxiation (death from lack of oxygen) without the painful and traumatic feeling of suffocation (the hypercapnic alarm response, which in humans arises mostly from carbon dioxide levels rising), or the side effects of poisoning. In scuba diving rebreather accidents, there is often little sensation but euphoria—however, a slow decrease in oxygen breathing gas content has effects which are quite variable. By contrast, suddenly breathing pure inert gas causes oxygen levels in the blood to fall precipitously, and may lead to unconsciousness in only a few breaths, with no symptoms at all.
Some animal species are better equipped than humans to detect hypoxia, and these species are more uncomfortable in low-oxygen environments that result from inert gas exposure.
A typical human breathes between 12 and 20 times per minute at a rate primarily influenced by carbon dioxide concentration, and thus pH, in the blood. With each breath, a volume of about 0.6 litres is exchanged from an active lung volume (tidal volume + functional residual capacity) of about 3 litres. Normal Earth atmosphere is about 78% nitrogen, 21% oxygen, and 1% argon, carbon dioxide, and other gases. After just two or three breaths of nitrogen, the oxygen concentration in the lungs would be low enough for some oxygen already in the bloodstream to exchange back to the lungs and be eliminated by exhalation. Crude simulation of oxygen transport through the lungs and bloodstream suggests that the partial pressure of oxygen in arterial blood would be about 50% of saturation 1 minute after switching gases and would reach zero within 3 minutes.
Unconsciousness in cases of accidental asphyxia can occur within 1 minute. Loss of consciousness results from critical hypoxia, when arterial oxygen saturation is less than 60%. "At oxygen concentrations [in air] of 4 to 6%, there is loss of consciousness in 40 seconds and death within a few minutes". As [clarification needed] provides an atmosphere completely devoid of oxygen, the sequence of effects should be expected to occur even more quickly. At an altitude over 43,000 ft (13,000 m), where the ambient oxygen concentration is equivalent to 3.6% at sea level, an average individual can perform flying duties efficiently for only 9 to 12 seconds without oxygen supplementation. The US Air Force trains air crews to recognize their individual subjective signs of approaching hypoxia. Some individuals experience headache, dizziness, fatigue, nausea, euphoria and some become unconscious without warning.
Relation to controlled atmosphere killing
Controlled atmosphere killing (CAK) or controlled atmosphere stunning (CAS) is a method for slaughtering animals such as chickens by placing the animals in a container in which the atmosphere lacks oxygen and consists of an asphyxiant gas (one or more of argon, nitrogen or carbon dioxide), causing the animals to lose consciousness. Argon and nitrogen are important components of a gassing process which seem to cause no pain, and for this reason many consider some types of controlled atmosphere killing more humane than other methods of killing. If carbon dioxide is used, controlled atmosphere killing is not the same as inert gas asphyxia, because carbon dioxide at high concentrations (above 5%) is not biologically inert, but rather is toxic and also produces initial distress in a number of animal species. The addition of toxic carbon dioxide to hypoxic atmospheres used in slaughter without animal distress, is a complex and highly species-specific matter, which also depends on concentration of carbon dioxide.
Euthanasia of animals
Diving animals such as mink and burrowing animals, such as rodents and rats, are sensitive to low-oxygen atmospheres and (unlike humans) will avoid them, making purely hypoxic techniques possibly inhumane for them. For this reason, the use of inert gas (hypoxic) atmospheres (without CO2) for euthanasia, is also species-specific.
Accidental deaths and injury
Hypoxic atmospheres on land
Accidental nitrogen asphyxiation is a possible hazard where large quantities of nitrogen are used.
Accidental nitrogen asphyxiation causes about eight deaths per year in the United States, which is asserted to be more than from any other industrial gas. This figure comes from the fact that some 80 people were recorded killed in such accidents from 1992 to 2002.
In a notable accident in 1981, shortly before the launch of the first Space Shuttle mission, two technicians lost consciousness and one of them died after they entered the Orbiter aft compartment which was pressurized with pure nitrogen as a precaution against fire.
Occasional deaths are reported from recreational inhalation of helium, but these are very rare from direct inhalation from small balloons. The inhalation from larger helium balloons has been reportedly fatal. A fatal accidental fall from a tree occurred after the inhalation of Helium from a toy balloon, causing the person to become either unconscious or light headed.
In 2015, a technician at a health spa was likely asphyxiated or else frozen to death while conducting unsupervised cryotherapy using nitrogen.
Use of inert gas for suicide was first proposed by a Canadian, Dr Bruce Dunn. Dunn commented that, "...the acquisition of a compressed gas cylinder, an appropriate pressure reducing regulator, and suitable administration equipment... [was] "not inaccessible to a determined individual, but relatively difficult for a member of the public to acquire casually or quickly." Dunn collaborated with other researchers, notably the Canadian campaigner, John Hofsess, who in 1997 formed the group "NuTech" with Derek Humphry and Philip Nitschke. Two years later, NuTech had streamlined Dunn's work by using readily-available party balloon cylinders of helium.
The method of suicide based on self-administration of helium in a bag, a colloquial name being the "exit bag" or suicide bag, has been referenced by some medical euthanasia advocacy groups. Originally such bags were used with helium, and 30 deaths were reported with use of them from 2001 to 2005, and another 79 from 2005 to 2009. This suggested to one set of reviewers that the popularity of the technique was increasing, as also did the increase in helium suicides in Sweden during the latter half of the same decade.
After attempts were made by authorities to control helium sales in Australia, a new method was introduced that instead uses nitrogen. Nitrogen became the main gas promoted by euthanasia advocates, such as Philip Nitschke, who founded a company called Max Dog Brewing in order to import canisters of nitrogen into Australia. Nitschke stated that the gas cylinders can be used for both brewing and, if required, to end life at a later stage in a "peaceful, reliable [and] totally legal" manner. Nitschke said, "[nitrogen] was undetectable even by autopsy, which was important to some people".
After a number of accidents in which humans suffocated in nitrogen without any warning, the suggestion was made in 1995 that hypoxic atmospheres might be used for a more humane form of execution.
Execution by nitrogen asphyxiation was discussed briefly in print as a theoretical method of capital punishment in a National Review article, "Killing with kindness – capital punishment by nitrogen asphyxiation". The idea was then proposed by Lawrence J. Gist II, an attorney at law, under the title, International Humanitarian Hypoxia Project.
In a televised documentary in 2007, the British political commentator (and former Member of Parliament) Michael Portillo examined execution techniques in use around the world and found them unsatisfactory; his conclusion was that nitrogen asphyxiation would be the best method.
- European Industrial Gases Association (2009), Hazards of Inert Gases and Oxygen Depletion, IGC Doc 44/09/E
- “Argon, hydrogen, helium, and nitrogen are inert gases that cause asphyxiation if present in high enough concentration to dilute O2 in the inspired air to dangerous levels. […] Asphyxia, which is synonymous with respiratory failure, can be defined as insufficient oxygen at the cellular level. […] Simple asphyxiants are gases that are physiologically inert. They do not suppress cardiac output or alter the function of the hemoglobin. Rather, they cause asphyxiation only when present in high enough concentration to lower the concentration of O2 in the inspired air to levels at which the SaO2 and PaO2 fall, resulting in inadequate O2 delivery to tissues.” Quoted from Simple Asphyxiants, Mark Wilkenfield, M.D. Chapter 34, pp. 556-7. in: Environmental and Occupational Medicine Editors William N. Rom, Steven B. Markawitz. 4th Edition, Publisher: Lippincott Williams & Wilkins, 2007. ISBN 0781762995, 9780781762991.
- Chemical Safety Board Bulletin This is a government summary of accidental 80 nitrogen inhalation deaths, mostly in occupational circumstances. For a presentation form with additional material, see 
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With [prolonged or acute hypoxia] there may be convulsions and eventual failure of the respiratory center.
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- The Animal Welfare Foundation of Canada article The Disposal of Spent Laying Hens by Jacqueline Wepruk
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- Welfare implications of the gas stunning of pigs 1. Determination of aversion to the initial inhalation of carbon dioxide or argon. Animal Welfare, 4: 273-280.
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- Lung ruptures and fatal gas embolisms have occurred from inhalation from a pressure tank and although this was reported as a helium inhalation death, it differs greatly from the process of inert gas asphyxiation. See gas embolism helium death
- Dunn B, Nitrogen and other Inert Gases. In: Smith K, Docker C, Hofsess J, Dunn B, "Beyond Final Exit." Published by the Right to Die Society of Canada 1995, pp.65-71. The book was distributed internationally by Canadian, American, and British organizations. See also Exit (Right-to-Die Organisation)
- "Dunn B, Beyond Final Exit, p.70. Dunn's work and other chapters from Beyond Final Exit was also publicised on the Canadian website (now offline) called DeathNET. Côte R, In Search of Gentle Death, Corinthian Books 2012, page 314.
- See: Euthanasia device
- Grassberger M, Krauskopf A. "Suicidal asphyxiation with helium: report of three cases.". nih.gov.
- Recent trends in suicides utilizing helium Increasing frequency of helium gas suicide in Australia and Sweden; review of recent trends. This is a review, as the authors did not do the autopsies of the more than 109 of these suicides autopsies across Australia and 7 in Sweden between 2001-9.
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- Orr, Aleisha (3 May 2013). "Euthanasia group to show West Aussies how to die 'well'". WAToday. Retrieved 8 May 2013.
- Creque, S.A. "Killing with kindness – capital punishment by nitrogen asphyxiation" National Review. 1995-9-11.
- "How to Kill a Human Being - in search of a painless death". VideoSift.
- NIOSH respirator fact sheet
- U.S. Chemical Safety and Hazard Investigation Board
- Death Penalty Information Center
- Restraint asphyxia
- The Welfare of Birds at Slaughter: Humane Society of the United States comparison of controlled-atmosphere killing (CAK) to electrical water-bath stunning
- Controlled Atmosphere Killing: People for the Ethical Treatment of Animals
- Mcgee, Kimberley; Turkewitz, Julie (2015-10-26). "Death of Woman in Tank at a Nevada Cryotherapy Center Raises Questions About Safety". The New York Times. ISSN 0362-4331. Retrieved 2016-01-26.