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'Metabolic wastes or excretes are substances left over from metabolic processes (such as cellular respiration), which cannot be used by the organism (they are surplus or toxic), and must therefore be excreted. This includes nitrogen compounds, water, CO2, phosphates, sulfates, etc. Animals treat these compounds as excretes. Plants have chemical "machinery" which transforms some of them (primarily the nitrogen compounds) into useful substances, and it has been shown by Brian J. Ford that abscissa leaves also carry wastes away from the parent plant. In this way, Ford argues that the shed leaf acts as an excretory (an organ carrying away excretory products).
All the metabolic wastes are excreted in a form of water solutes through the excretory organs (nephridia, Malpighian tubules, kidneys), with the exception of CO2, which is excreted together with the water vapor throughout the lungs. The elimination of these compounds enables the chemical homeostasis of the organism.
The nitrogen compounds through which excess nitrogen is eliminated from organisms are called nitrogenous wastes (//) or nitrogen wastes. They are ammonia, urea, uric acid, and creatinine. All of these substances are produced from protein metabolism. In many animals, the urine is the main route of excretion for such wastes; in some, the feces is.
Ammonia (NH3) forms with the oxidation of amino groups (NH2), which are removed from the proteins when they convert into carbohydrates. It is a very toxic substance to tissues and extremely soluble in water. Only one nitrogen atom is removed with it. A lot of water is needed for the excretion of ammonia, about 0.5 L of water is needed per 1 g of nitrogen to maintain ammonia levels in the excretory fluid below the level in body fluids to prevent toxicity. Thus, the marine organisms excrete ammonia directly into the water and are called ammonotelic.  Ammonetelic animals include protozoans, crustaceans, platyhelminths, cnidarians, poriferans, echinoderms, and other aquatic invertebrates,
Land animals mainly amphibians and mammals convert ammonia into urea, a process which occurs in the liver and kidney. These animals are called ureotelic. Urea is a less toxic compound than ammonia; two nitrogen atoms are eliminated through it and less water is needed for its excretion.It requires 0.05 L of water to excrete 1 g of nitrogen, approximately only 10% of that required in ammonotelic organisms.
Uricotelism is the ridding of excess nitrogen using uric acid. This method is used by birds and diapsids, insects, lizards, and snakes, and these animals are called uricoletic. Uric acid is less toxic than ammonia or urea. It contains four nitrogen atoms and only a small amount of water (about 0.001 L per 1 g of nitrogen) is needed for its excretion. Uric acid is the least soluble in water and can be stored in cells and body tissues without toxic effects. A single molecule of uric acid can remove four atoms of nitrogen making it more efficient than ammonetelism and ureotelism.
Uricotelic organisms typically have white pasty excreta. Some mammals including humans excrete uric acid as a component of urea but it is only a small amount.
Water and gases
These compounds form during the catabolism of carbohydrates and lipids in condensation reactions, and in some other metabolic reactions of the amino acids. Oxygen is produced by plants and some bacteria in photosynthesis, while CO2 is a waste product of all animals and plants. Nitrogen gases are produced by denitrifying bacteria and as a waste product, and bacteria for decaying yield ammonia, as do most invertebrates and vertebrates. Water is the only liquid waste from animals and photosynthesizing plants.
Nitrates and nitrites are wastes produced by nitrifying bacteria, just as sulfur and sulfates are produced by sulfur-reducing bacteria and sulfate-reducing bacteria. Insoluble iron waste can be made by iron bacteria by using soluble forms. In plants, resins, fats, waxes, and complex organic chemicals are exuded from plants, e.g., the latex from rubber trees and milkweeds. Solid waste products may be manufactured as organic pigments derived from breakdown of pigments like hemoglobin, and inorganic salts like carbonates, bicarbonates, and phosphate, whether in ionic or molecular form, are excreted as solids.
- Chris M. Wood; R.S. Munger; D.P. Toews (1989). "Ammonia, urea, and H+ distribution and the evolution of ureotelism in amphibians" (PDF). Journal of Experimental Biology. 144: 215–233.
- S. Sreekumar (2010). Basic Physiology. PHI Learning Pvt. Ltd. p. 180–181. ISBN 9788120341074.
- "excretion." Encyclopædia Britannica. Encyclopaedia Britannica Ultimate Reference Suite. Chicago: Encyclopædia Britannica, 2010.